Role of oncogenic REGγ in cancer
Cancer is a critical global health-care problem with limited therapeutic options. Since cancers are life-threatening illnesses, the identification of a promising oncotarget and its clinical correlates are relevant. Mounting evidence has emerged indicating that REG gamma (REGγ), a member of the 11S p...
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doaj-d50fd3a0b059490c9393c9e5a38679982021-05-20T07:43:32ZengElsevierBiomedicine & Pharmacotherapy0753-33222020-10-01130110614Role of oncogenic REGγ in cancerMaolei Shen0Qinzhang Wang1Shuaijun Xu2Guang Chen3Hao Xu4Xin Li5Shankun Zhao6Department of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, ChinaDepartment of Urology, The First Affiliated Hospital of Shihezi University Medical School, Shihezi, ChinaHebei North University, Zhangjiakou, 075000, Hebei, ChinaDepartment of Pharmacology, School of Medicine, Taizhou University, Taizhou, 318000, Zhejiang, ChinaHealth Company, 69235, Army of PLA, ChinaDepartment of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, ChinaDepartment of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, China; Corresponding author.Cancer is a critical global health-care problem with limited therapeutic options. Since cancers are life-threatening illnesses, the identification of a promising oncotarget and its clinical correlates are relevant. Mounting evidence has emerged indicating that REG gamma (REGγ), a member of the 11S proteasome activators, plays a pivotal role in the development of multiple human cancers. However, an elaborate summary on the association between REGγ and cancer is still lacking. In this Review, we discuss how REGγ, through its ATP- and ubiquitin-independent manners, represents a promising cancer biomarker and therapeutic oncotarget for multiple human cancers. Aberrant REGγ expression closely associated with tumorigenesis attributes to its biological functions for controlling and regulating cell cycle, proliferation, migration, invasion, angiogenesis, and metastasis of the cancer cells by degrading proteins of cytosol and nucleus in the eukaryotic cells. REGγ serves as a molecular switch to activate multifarious oncogenic signaling pathways, such as MAPK/p38, TGF-β/Smad, and Wnt/β-catenin. The review describes that targeting REGγ may provide new diagnostic and therapeutic applications in cancer.http://www.sciencedirect.com/science/article/pii/S0753332220308076REGγCancerPathogenesisOncogeneBiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maolei Shen Qinzhang Wang Shuaijun Xu Guang Chen Hao Xu Xin Li Shankun Zhao |
spellingShingle |
Maolei Shen Qinzhang Wang Shuaijun Xu Guang Chen Hao Xu Xin Li Shankun Zhao Role of oncogenic REGγ in cancer Biomedicine & Pharmacotherapy REGγ Cancer Pathogenesis Oncogene Biomarker |
author_facet |
Maolei Shen Qinzhang Wang Shuaijun Xu Guang Chen Hao Xu Xin Li Shankun Zhao |
author_sort |
Maolei Shen |
title |
Role of oncogenic REGγ in cancer |
title_short |
Role of oncogenic REGγ in cancer |
title_full |
Role of oncogenic REGγ in cancer |
title_fullStr |
Role of oncogenic REGγ in cancer |
title_full_unstemmed |
Role of oncogenic REGγ in cancer |
title_sort |
role of oncogenic regγ in cancer |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2020-10-01 |
description |
Cancer is a critical global health-care problem with limited therapeutic options. Since cancers are life-threatening illnesses, the identification of a promising oncotarget and its clinical correlates are relevant. Mounting evidence has emerged indicating that REG gamma (REGγ), a member of the 11S proteasome activators, plays a pivotal role in the development of multiple human cancers. However, an elaborate summary on the association between REGγ and cancer is still lacking. In this Review, we discuss how REGγ, through its ATP- and ubiquitin-independent manners, represents a promising cancer biomarker and therapeutic oncotarget for multiple human cancers. Aberrant REGγ expression closely associated with tumorigenesis attributes to its biological functions for controlling and regulating cell cycle, proliferation, migration, invasion, angiogenesis, and metastasis of the cancer cells by degrading proteins of cytosol and nucleus in the eukaryotic cells. REGγ serves as a molecular switch to activate multifarious oncogenic signaling pathways, such as MAPK/p38, TGF-β/Smad, and Wnt/β-catenin. The review describes that targeting REGγ may provide new diagnostic and therapeutic applications in cancer. |
topic |
REGγ Cancer Pathogenesis Oncogene Biomarker |
url |
http://www.sciencedirect.com/science/article/pii/S0753332220308076 |
work_keys_str_mv |
AT maoleishen roleofoncogenicreggincancer AT qinzhangwang roleofoncogenicreggincancer AT shuaijunxu roleofoncogenicreggincancer AT guangchen roleofoncogenicreggincancer AT haoxu roleofoncogenicreggincancer AT xinli roleofoncogenicreggincancer AT shankunzhao roleofoncogenicreggincancer |
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