Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues

Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues

To investigate the role of cAMP resposive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner....

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Bibliographic Details
Main Authors: Carles Sanchis-Segura, Dragana Jancic, Maria Jimenez-Minchan, Angel Barco
Format: Article
Language:English
Published: Frontiers Media S.A. 2009-09-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Morphine
Addiction
CREB
Place Preference
dorsal striatum
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.08.030.2009/full

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