Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues
Epithelial tissues protecting organs from the environment are the first-line of defense against pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain epithelial integrity. However, these healing processes can be insufficient to restore epithelial integrity, notably i...
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doaj-d52337aa9bca47fa993c6d5cf2139dce2020-11-25T03:26:43ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882019-05-01910.3389/fcimb.2019.00182445683Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic AvenuesManon Ruffin0Manon Ruffin1Manon Ruffin2Emmanuelle Brochiero3Emmanuelle Brochiero4Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, CanadaDépartement de Médecine, Université de Montréal, Montréal, QC, CanadaINSERM, Centre de Recherche Saint-Antoine, CRSA, Sorbonne Université, Paris, FranceCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, CanadaDépartement de Médecine, Université de Montréal, Montréal, QC, CanadaEpithelial tissues protecting organs from the environment are the first-line of defense against pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain epithelial integrity. However, these healing processes can be insufficient to restore epithelial integrity, notably in infectious conditions. Pseudomonas aeruginosa infections in cutaneous, corneal, and respiratory tract epithelia are of particular concern because they are the leading causes of hospitalizations, disabilities, and deaths worldwide. Pseudomonas aeruginosa has been shown to alter repair processes, leading to chronic wounds and infections. Because of the current increase in the incidence of multi-drug resistant isolates of P. aeruginosa, complementary approaches to decrease the negative impact of these bacteria on epithelia are urgently needed. Here, we review the recent advances in the understanding of the impact of P. aeruginosa infections on the integrity and repair mechanisms of alveolar, airway, cutaneous and corneal epithelia. Potential therapeutic avenues aimed at counteracting this deleterious impact of infection are also discussed.https://www.frontiersin.org/article/10.3389/fcimb.2019.00182/fullPseudomonas aeruginosa infectionsepithelial repairwound repairskinburnlung |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manon Ruffin Manon Ruffin Manon Ruffin Emmanuelle Brochiero Emmanuelle Brochiero |
spellingShingle |
Manon Ruffin Manon Ruffin Manon Ruffin Emmanuelle Brochiero Emmanuelle Brochiero Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues Frontiers in Cellular and Infection Microbiology Pseudomonas aeruginosa infections epithelial repair wound repair skin burn lung |
author_facet |
Manon Ruffin Manon Ruffin Manon Ruffin Emmanuelle Brochiero Emmanuelle Brochiero |
author_sort |
Manon Ruffin |
title |
Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues |
title_short |
Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues |
title_full |
Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues |
title_fullStr |
Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues |
title_full_unstemmed |
Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues |
title_sort |
repair process impairment by pseudomonas aeruginosa in epithelial tissues: major features and potential therapeutic avenues |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2019-05-01 |
description |
Epithelial tissues protecting organs from the environment are the first-line of defense against pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain epithelial integrity. However, these healing processes can be insufficient to restore epithelial integrity, notably in infectious conditions. Pseudomonas aeruginosa infections in cutaneous, corneal, and respiratory tract epithelia are of particular concern because they are the leading causes of hospitalizations, disabilities, and deaths worldwide. Pseudomonas aeruginosa has been shown to alter repair processes, leading to chronic wounds and infections. Because of the current increase in the incidence of multi-drug resistant isolates of P. aeruginosa, complementary approaches to decrease the negative impact of these bacteria on epithelia are urgently needed. Here, we review the recent advances in the understanding of the impact of P. aeruginosa infections on the integrity and repair mechanisms of alveolar, airway, cutaneous and corneal epithelia. Potential therapeutic avenues aimed at counteracting this deleterious impact of infection are also discussed. |
topic |
Pseudomonas aeruginosa infections epithelial repair wound repair skin burn lung |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2019.00182/full |
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