Rapid generation of hypomorphic mutations
Hypomorphic mutations are a valuable tool for analysing gene function, but current methods have difficult to predict effects on gene expression and are organism specific. Here the authors present a pan-species approach using variable polyA tracks to modulate expression of a target protein.
Bibliographic Details
| Main Authors: |
Laura L. Arthur,
Joyce J. Chung,
Preetam Janakirama,
Kathryn M. Keefer,
Igor Kolotilin,
Slavica Pavlovic-Djuranovic,
Douglas L. Chalker,
Vojislava Grbic,
Rachel Green,
Rima Menassa,
Heather L. True,
James B. Skeath,
Sergej Djuranovic |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14112
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