Rapid generation of hypomorphic mutations

Rapid generation of hypomorphic mutations

Hypomorphic mutations are a valuable tool for analysing gene function, but current methods have difficult to predict effects on gene expression and are organism specific. Here the authors present a pan-species approach using variable polyA tracks to modulate expression of a target protein.

Bibliographic Details
Main Authors: Laura L. Arthur, Joyce J. Chung, Preetam Janakirama, Kathryn M. Keefer, Igor Kolotilin, Slavica Pavlovic-Djuranovic, Douglas L. Chalker, Vojislava Grbic, Rachel Green, Rima Menassa, Heather L. True, James B. Skeath, Sergej Djuranovic
Format: Article
Language:English
Published: Nature Publishing Group 2017-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14112

Internet

https://doi.org/10.1038/ncomms14112

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