Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates

Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.

Bibliographic Details
Main Authors:	Olena Kis, Rayan Kaedbey, Signy Chow, Arnavaz Danesh, Mark Dowar, Tiantian Li, Zhihua Li, Jessica Liu, Mark Mansour, Esther Masih-Khan, Tong Zhang, Scott V. Bratman, Amit M. Oza, Suzanne Kamel-Reid, Suzanne Trudel, Trevor J. Pugh
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15086

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spelling	doaj-d52e507d56a94e48a45f62b403d8d6ed2021-05-11T07:46:16ZengNature Publishing GroupNature Communications2041-17232017-05-018111110.1038/ncomms15086Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspiratesOlena Kis0Rayan Kaedbey1Signy Chow2Arnavaz Danesh3Mark Dowar4Tiantian Li5Zhihua Li6Jessica Liu7Mark Mansour8Esther Masih-Khan9Tong Zhang10Scott V. Bratman11Amit M. Oza12Suzanne Kamel-Reid13Suzanne Trudel14Trevor J. Pugh15Princess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkGenetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.https://doi.org/10.1038/ncomms15086
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Olena Kis Rayan Kaedbey Signy Chow Arnavaz Danesh Mark Dowar Tiantian Li Zhihua Li Jessica Liu Mark Mansour Esther Masih-Khan Tong Zhang Scott V. Bratman Amit M. Oza Suzanne Kamel-Reid Suzanne Trudel Trevor J. Pugh
spellingShingle	Olena Kis Rayan Kaedbey Signy Chow Arnavaz Danesh Mark Dowar Tiantian Li Zhihua Li Jessica Liu Mark Mansour Esther Masih-Khan Tong Zhang Scott V. Bratman Amit M. Oza Suzanne Kamel-Reid Suzanne Trudel Trevor J. Pugh Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates Nature Communications
author_facet	Olena Kis Rayan Kaedbey Signy Chow Arnavaz Danesh Mark Dowar Tiantian Li Zhihua Li Jessica Liu Mark Mansour Esther Masih-Khan Tong Zhang Scott V. Bratman Amit M. Oza Suzanne Kamel-Reid Suzanne Trudel Trevor J. Pugh
author_sort	Olena Kis
title	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_short	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_full	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_fullStr	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_full_unstemmed	Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates
title_sort	circulating tumour dna sequence analysis as an alternative to multiple myeloma bone marrow aspirates
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-05-01
description	Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.
url	https://doi.org/10.1038/ncomms15086
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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates

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