Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations
Abstract Background Vitamin D metabolism and obesity have been linked by several studies, however the reason for this association is unclear. Our objective was to investigate potential correlations between genetic variants in key enzymes of vitamin D metabolism and the body mass index on a represent...
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doaj-d538abbb320d4f3d995725b320088a2c2021-04-02T09:24:22ZengBMCBMC Medical Genetics1471-23502020-06-012111810.1186/s12881-020-01065-3Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrationsBence Bakos0Balázs Szili1Boglárka Szabó2Péter Horváth3Gyöngyi Kirschner4János P. Kósa5Erzsébet Toldy6Péter Lakatos7Ádám G. Tabák8István Takács9Department of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineDepartment of Pulmonology, Semmelweis University Faculty of MedicineDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineClinical Chemistry and Immunology Laboratories, SYNLAB Diagnostic CentreDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineDepartment of Internal Medicine and Oncology, Semmelweis University Faculty of MedicineAbstract Background Vitamin D metabolism and obesity have been linked by several studies, however the reason for this association is unclear. Our objective was to investigate potential correlations between genetic variants in key enzymes of vitamin D metabolism and the body mass index on a representative and random sample of Hungarian adults. Methods Altogether 462 severely vitamin D deficient individuals were studied at the end of winter in order to decrease environmental and maximize any relevant genetic effect. Furthermore, participants with lifestyle factors known to affect vitamin D homeostasis were also excluded. We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR). Results Variants in 2 genetic polymorphisms; rs2853564 (VDR) and rs11023374 (CYP2R1) showed a significant association with participants‘ BMI. These associations survived further adjustment for total-, free-, or bioactive-25(OH) vitamin D levels, although the variance explained by these 2 SNPS in BMI heterogeneity was only 3.2%. Conclusion Our results show two novel examples of the relationship between genetics of vitamin D and BMI, highlighting the potential role of vitamin D hormone in the physiology of obesity.http://link.springer.com/article/10.1186/s12881-020-01065-3Vitamin DBMIGeneticsVDRCYP2R1 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bence Bakos Balázs Szili Boglárka Szabó Péter Horváth Gyöngyi Kirschner János P. Kósa Erzsébet Toldy Péter Lakatos Ádám G. Tabák István Takács |
spellingShingle |
Bence Bakos Balázs Szili Boglárka Szabó Péter Horváth Gyöngyi Kirschner János P. Kósa Erzsébet Toldy Péter Lakatos Ádám G. Tabák István Takács Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations BMC Medical Genetics Vitamin D BMI Genetics VDR CYP2R1 |
author_facet |
Bence Bakos Balázs Szili Boglárka Szabó Péter Horváth Gyöngyi Kirschner János P. Kósa Erzsébet Toldy Péter Lakatos Ádám G. Tabák István Takács |
author_sort |
Bence Bakos |
title |
Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations |
title_short |
Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations |
title_full |
Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations |
title_fullStr |
Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations |
title_full_unstemmed |
Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations |
title_sort |
genetic variants of vdr and cyp2r1 affect bmi independently of serum vitamin d concentrations |
publisher |
BMC |
series |
BMC Medical Genetics |
issn |
1471-2350 |
publishDate |
2020-06-01 |
description |
Abstract Background Vitamin D metabolism and obesity have been linked by several studies, however the reason for this association is unclear. Our objective was to investigate potential correlations between genetic variants in key enzymes of vitamin D metabolism and the body mass index on a representative and random sample of Hungarian adults. Methods Altogether 462 severely vitamin D deficient individuals were studied at the end of winter in order to decrease environmental and maximize any relevant genetic effect. Furthermore, participants with lifestyle factors known to affect vitamin D homeostasis were also excluded. We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR). Results Variants in 2 genetic polymorphisms; rs2853564 (VDR) and rs11023374 (CYP2R1) showed a significant association with participants‘ BMI. These associations survived further adjustment for total-, free-, or bioactive-25(OH) vitamin D levels, although the variance explained by these 2 SNPS in BMI heterogeneity was only 3.2%. Conclusion Our results show two novel examples of the relationship between genetics of vitamin D and BMI, highlighting the potential role of vitamin D hormone in the physiology of obesity. |
topic |
Vitamin D BMI Genetics VDR CYP2R1 |
url |
http://link.springer.com/article/10.1186/s12881-020-01065-3 |
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