Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes
We report a case of acute-onset type 1 diabetes due to combined application of nivolumab and intravesical Bacillus Calmette-Guérin (BCG). An 84-year-old woman underwent lung resection for pulmonary squamous cell carcinoma. She had been treated for type 2 diabetes and later experienced lung cancer re...
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doaj-d53ad47cad6143a4bacb4b23806e42d22020-11-25T00:59:18ZengKarger PublishersCase Reports in Oncology1662-65752019-06-0112243043310.1159/000500978500978Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 DiabetesKoichi FujiuYasuo FukayaMasahiro KamimotoHideaki MiyamotoYue CongHiroyuki SuzukiWe report a case of acute-onset type 1 diabetes due to combined application of nivolumab and intravesical Bacillus Calmette-Guérin (BCG). An 84-year-old woman underwent lung resection for pulmonary squamous cell carcinoma. She had been treated for type 2 diabetes and later experienced lung cancer recurrence. She was started on nivolumab treatment, and complete response was achieved for one year. However, during this time, she was diagnosed with superficial bladder cancer and underwent surgery but experienced recurrence. After one month of intravesical BCG instillation, the patient developed acute-onset type 1 diabetes. Thus, we recommend that combined application of nivolumab and intravesical BCG be avoided.https://www.karger.com/Article/FullText/500978Type 1 diabetesNivolumabLung cancerIntravesical BCGPD-L1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Koichi Fujiu Yasuo Fukaya Masahiro Kamimoto Hideaki Miyamoto Yue Cong Hiroyuki Suzuki |
spellingShingle |
Koichi Fujiu Yasuo Fukaya Masahiro Kamimoto Hideaki Miyamoto Yue Cong Hiroyuki Suzuki Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes Case Reports in Oncology Type 1 diabetes Nivolumab Lung cancer Intravesical BCG PD-L1 |
author_facet |
Koichi Fujiu Yasuo Fukaya Masahiro Kamimoto Hideaki Miyamoto Yue Cong Hiroyuki Suzuki |
author_sort |
Koichi Fujiu |
title |
Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes |
title_short |
Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes |
title_full |
Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes |
title_fullStr |
Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes |
title_full_unstemmed |
Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes |
title_sort |
combined application of nivolumab and intravesical bacillus calmette-guérin led to acute-onset type 1 diabetes |
publisher |
Karger Publishers |
series |
Case Reports in Oncology |
issn |
1662-6575 |
publishDate |
2019-06-01 |
description |
We report a case of acute-onset type 1 diabetes due to combined application of nivolumab and intravesical Bacillus Calmette-Guérin (BCG). An 84-year-old woman underwent lung resection for pulmonary squamous cell carcinoma. She had been treated for type 2 diabetes and later experienced lung cancer recurrence. She was started on nivolumab treatment, and complete response was achieved for one year. However, during this time, she was diagnosed with superficial bladder cancer and underwent surgery but experienced recurrence. After one month of intravesical BCG instillation, the patient developed acute-onset type 1 diabetes. Thus, we recommend that combined application of nivolumab and intravesical BCG be avoided. |
topic |
Type 1 diabetes Nivolumab Lung cancer Intravesical BCG PD-L1 |
url |
https://www.karger.com/Article/FullText/500978 |
work_keys_str_mv |
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