GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter

GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter

Abstract GABAergic interneurons play a critical role in tuning neural networks in the central nervous system, and their defects are associated with neuropsychiatric disorders. Currently, the mDlx enhancer is solely used for adeno-associated virus (AAV) vector-mediated transgene delivery into cortica...

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Bibliographic Details
Main Authors: Chiaki Hoshino, Ayumu Konno, Nobutake Hosoi, Ryosuke Kaneko, Ryo Mukai, Junichi Nakai, Hirokazu Hirai
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Brain
Subjects:
Interneuron
Inhibitory neuron
Chandelier cell
GAD65
Dlx
GABA
Online Access:https://doi.org/10.1186/s13041-021-00746-1

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