Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial
Abstract Background Anagliptin, a dipeptidyl peptidase-4 inhibitor, is reported to reduce the level of low-density lipoprotein cholesterol (LDL-C). The underlying mechanism of this effect and effect on lipid metabolism however remains uncertain. Aim and methods We therefore evaluate the effects of a...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-11-01
|
Series: | Cardiovascular Diabetology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12933-019-0965-3 |
id |
doaj-d5456baecff44bd08549ae6a396ff0ec |
---|---|
record_format |
Article |
spelling |
doaj-d5456baecff44bd08549ae6a396ff0ec2020-11-25T04:05:21ZengBMCCardiovascular Diabetology1475-28402019-11-011811810.1186/s12933-019-0965-3Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trialAtsuko Chihara0Atsushi Tanaka1Takeshi Morimoto2Mio Sakuma3Michio Shimabukuro4Takashi Nomiyama5Osamu Arasaki6Shinichiro Ueda7Koichi Node8Department of Cardiovascular Medicine, Saga UniversityDepartment of Cardiovascular Medicine, Saga UniversityDepartment of Clinical Epidemiology, Hyogo College of MedicineDepartment of Clinical Epidemiology, Hyogo College of MedicineDepartment of Diabetes, Endocrinology and Metabolism, Fukushima Medical UniversityDepartment of Endocrinology and Diabetes Mellitus, Fukuoka UniversityDepartment of Cardiology, Tomishiro Central HospitalDepartment of Pharmacology and Therapeutics, University of the RyukyusDepartment of Cardiovascular Medicine, Saga UniversityAbstract Background Anagliptin, a dipeptidyl peptidase-4 inhibitor, is reported to reduce the level of low-density lipoprotein cholesterol (LDL-C). The underlying mechanism of this effect and effect on lipid metabolism however remains uncertain. Aim and methods We therefore evaluate the effects of anagliptin on lipid metabolism-related markers compared with those of sitagliptin. The study was a secondary analysis using data obtained from the Randomized Evaluation of Anagliptin versus Sitagliptin On low-density lipoproteiN cholesterol in diabetes (REASON) trial. This trial in patients with type 2 diabetes at a high risk of cardiovascular events and on statin therapy showed that anagliptin reduced LDL-C levels to a greater extent than sitagliptin. Cholesterol absorption (campesterol and sitosterol) and synthesis (lathosterol) markers were measured at baseline and 52 weeks in the study cohort (n = 353). Results There was no significant difference in the changes of campesterol or sitosterol between the two treatment groups (p = 0.85 and 0.55, respectively). Lathosterol concentration was increased significantly at 52 weeks with sitagliptin treatment (baseline, 1.2 ± 0.7 μg/mL vs. 52 weeks, 1.4 ± 1.0 μg/mL, p = 0.02), whereas it did not change in the anagliptin group (baseline, 1.3 ± 0.8 μg/mL vs. 52 weeks, 1.3 ± 0.7 μg/mL, p = 0.99). The difference in absolute change between the two groups showed a borderline significance (p = 0.06). Conclusion These findings suggest that anagliptin reduces LDL-C level by suppressing excess cholesterol synthesis, even in combination with statin therapy. Trial registration ClinicalTrials.gov number NCT02330406. https://clinicaltrials.gov/ct2/show/NCT02330406; registered January 5, 2015.http://link.springer.com/article/10.1186/s12933-019-0965-3Type 2 diabetesAnagliptinSitagliptinLipid metabolismsLathosterol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Atsuko Chihara Atsushi Tanaka Takeshi Morimoto Mio Sakuma Michio Shimabukuro Takashi Nomiyama Osamu Arasaki Shinichiro Ueda Koichi Node |
spellingShingle |
Atsuko Chihara Atsushi Tanaka Takeshi Morimoto Mio Sakuma Michio Shimabukuro Takashi Nomiyama Osamu Arasaki Shinichiro Ueda Koichi Node Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial Cardiovascular Diabetology Type 2 diabetes Anagliptin Sitagliptin Lipid metabolisms Lathosterol |
author_facet |
Atsuko Chihara Atsushi Tanaka Takeshi Morimoto Mio Sakuma Michio Shimabukuro Takashi Nomiyama Osamu Arasaki Shinichiro Ueda Koichi Node |
author_sort |
Atsuko Chihara |
title |
Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial |
title_short |
Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial |
title_full |
Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial |
title_fullStr |
Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial |
title_full_unstemmed |
Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial |
title_sort |
differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the reason trial |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2019-11-01 |
description |
Abstract Background Anagliptin, a dipeptidyl peptidase-4 inhibitor, is reported to reduce the level of low-density lipoprotein cholesterol (LDL-C). The underlying mechanism of this effect and effect on lipid metabolism however remains uncertain. Aim and methods We therefore evaluate the effects of anagliptin on lipid metabolism-related markers compared with those of sitagliptin. The study was a secondary analysis using data obtained from the Randomized Evaluation of Anagliptin versus Sitagliptin On low-density lipoproteiN cholesterol in diabetes (REASON) trial. This trial in patients with type 2 diabetes at a high risk of cardiovascular events and on statin therapy showed that anagliptin reduced LDL-C levels to a greater extent than sitagliptin. Cholesterol absorption (campesterol and sitosterol) and synthesis (lathosterol) markers were measured at baseline and 52 weeks in the study cohort (n = 353). Results There was no significant difference in the changes of campesterol or sitosterol between the two treatment groups (p = 0.85 and 0.55, respectively). Lathosterol concentration was increased significantly at 52 weeks with sitagliptin treatment (baseline, 1.2 ± 0.7 μg/mL vs. 52 weeks, 1.4 ± 1.0 μg/mL, p = 0.02), whereas it did not change in the anagliptin group (baseline, 1.3 ± 0.8 μg/mL vs. 52 weeks, 1.3 ± 0.7 μg/mL, p = 0.99). The difference in absolute change between the two groups showed a borderline significance (p = 0.06). Conclusion These findings suggest that anagliptin reduces LDL-C level by suppressing excess cholesterol synthesis, even in combination with statin therapy. Trial registration ClinicalTrials.gov number NCT02330406. https://clinicaltrials.gov/ct2/show/NCT02330406; registered January 5, 2015. |
topic |
Type 2 diabetes Anagliptin Sitagliptin Lipid metabolisms Lathosterol |
url |
http://link.springer.com/article/10.1186/s12933-019-0965-3 |
work_keys_str_mv |
AT atsukochihara differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial AT atsushitanaka differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial AT takeshimorimoto differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial AT miosakuma differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial AT michioshimabukuro differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial AT takashinomiyama differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial AT osamuarasaki differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial AT shinichiroueda differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial AT koichinode differencesinlipidmetabolismbetweenanagliptinandsitagliptininpatientswithtype2diabetesonstatintherapyasecondaryanalysisofthereasontrial |
_version_ |
1724434500328357888 |