RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the intestine and the mechanisms of how they contribute to tumourigenesis remain unclear. Here, we show that RAL GTPases are necess...

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Bibliographic Details
Main Authors: Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
stem cells
intestinal regeneration
tumourigenesis
ral proteins
drosophila
EGFR signalling
Online Access:https://elifesciences.org/articles/63807

Internet

https://elifesciences.org/articles/63807

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