Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

In this study, a novel series of 1,2-disubstituted benzo[<i>d</i>]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect of replacing the 5-methylfuryl moiety of the well-known an...

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Bibliographic Details
Main Authors: Heba T. Abdel-Mohsen, Mona A. Abdullaziz, Ahmed M. El Kerdawy, Fatma A. F. Ragab, Keith J. Flanagan, Abeer E. E. Mahmoud, Mamdouh M. Ali, Hoda I. El Diwani, Mathias O. Senge
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
design
synthesis
1,2-disubstituted benzimidazole
vegfr-2
angiogenesis
hepg-2
Online Access:https://www.mdpi.com/1420-3049/25/4/770

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