Role of periostin in Iraqi asthmatic patients

• Main Authors: Ameera Jasim Al-Aaraji, Suhayr Aesa Al-Qaysi, Ali Salih Baay
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: Medical Journal of Babylon
• Subjects: Asthma; forced expiratory volume 1%; forced expiratory volume 1/forced vital capacity; periostin
• Online Access: http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2019;volume=16;issue=3;spage=256;epage=260;aulast=Al-Aaraji

Background: Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. The understanding of the pathogenesis of the disease is essential to improve the plan of management. Objective: The objective of this study is to identify the role of periostin as inflammatory biomarker of asthma. Materials and Methods: A total of 200 participants were enrolled in the study, of which there are 100 controls and 100 asthmatic patients. Blood samples were obtained from the participants for periostin investigations by enzyme-linked immunosorbent assay assay. Results: Serum periostin concentrations were significantly (P < 0.001) higher in asthmatic patients (mean ± standard deviation [SD]; 68.152±9.792) compared to control group (mean ± SD; 46.488 ± 4.237). Periostin correlated negatively with forced expiratory volume (FEV) 1% and FEV1/forced vital capacity (FVC) in asthmatic patients. Conclusions: Serum periostin is increased in Iraqi asthmatic patients compared to controls and periostin correlated negatively with FEV1% and FEV1/FVC in asthmatic patients. Asthma is the most significant variable relates to high periostin serum concentration.