Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity

Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity

Betulinic acid (BA) was demonstrated to be a very promising anticancer agent against various tumor cell lines such as breast, colon, lung, and brain. Despite its strong cytotoxic effect, betulinic acid exhibits low water solubility, feature that is reflected in its poor bioavailability. To overcome...

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Bibliographic Details
Main Authors: Mirela Nicolov, Roxana M. Ghiulai, Mirela Voicu, Marius Mioc, Adina Octavia Duse, Roxana Roman, Rita Ambrus, Istvan Zupko, Elena Alina Moaca, Dorina E. Coricovac, Claudia Farcas, Roxana Marcela Racoviceanu, Corina Danciu, Cristina-Adriana Dehelean, Codruta Soica
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Chemistry
Subjects:
cocrystal
betulinic acid
vitamin C
antioxidant activity
antiproliferative activity
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00092/full

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