A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

<p>Abstract</p> <p>Synaptic transmission and long-term potentiation (LTP) in the CA1 region of hippocampal slices have been studied during ageing of a double transgenic mouse strain relevant to early-onset familial Alzheimer's disease (AD). This strain, which over-expresses bo...

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Bibliographic Details
Main Authors:	Fitzjohn Stephen M, Kuenzi Frederick, Morton Robin A, Rosahl Thomas W, Lewis Huw, Smith David, Seabrook Guy R, Collingridge Graham L
Format:	Article
Language:	English
Published:	BMC 2010-07-01
Series:	Molecular Brain
Online Access:	http://www.molecularbrain.com/content/3/1/21

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