Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging
Rhus javanica has long been used in traditional medicines, and found to possess bioactive properties. In this study, we sought to investigate whether Rhus javanica extract (RJE) has preventive effects against UVB-induced inflammation and photoaging. RJE was identified as a promising candidate based...
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doaj-d5863ddfcae54d15bdc6b725656216482021-04-30T07:08:56ZengElsevierJournal of Functional Foods1756-46462016-12-0127589599Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoagingSu Jeong Ha0Jangho Lee1Hyojin Kim2Kyung-Mo Song3Nam Hyouck Lee4Young Eon Kim5Hookeun Lee6Yong Ho Kim7Sung Keun Jung8Division of Functional Food Research, Korea Food Research Institute, Gyeonggi-do, 463-746, Republic of KoreaFood Biotechnology Program, Korea University of Science and Technology, Daejeon 305-350, Republic of KoreaInstitute of Pharmaceutical Research, College of Pharmacy, Gachon University, Incheon 21936, Republic of KoreaDivision of Functional Food Research, Korea Food Research Institute, Gyeonggi-do, 463-746, Republic of KoreaDivision of Functional Food Research, Korea Food Research Institute, Gyeonggi-do, 463-746, Republic of KoreaDivision of Functional Food Research, Korea Food Research Institute, Gyeonggi-do, 463-746, Republic of KoreaInstitute of Pharmaceutical Research, College of Pharmacy, Gachon University, Incheon 21936, Republic of KoreaDivision of Functional Food Research, Korea Food Research Institute, Gyeonggi-do, 463-746, Republic of Korea; Corresponding author. Division of Functional Food Research, Korea Food Research Institute, Gyeonggi-do, 463-746, Republic of Korea. Fax: +82 31 709 9876.Division of Functional Food Research, Korea Food Research Institute, Gyeonggi-do, 463-746, Republic of Korea; Food Biotechnology Program, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea; Corresponding author. Division of Functional Food Research, Korea Food Research Institute, Gyeonggi-do, 463-746, Republic of Korea. Fax: +82 31 709 9876.Rhus javanica has long been used in traditional medicines, and found to possess bioactive properties. In this study, we sought to investigate whether Rhus javanica extract (RJE) has preventive effects against UVB-induced inflammation and photoaging. RJE was identified as a promising candidate based on an MMP-1 promoter assay, and we confirmed suppressive effects on UVB-induced COX-2 and MMP-1 expression (67.6% and 80.9%, respectively) in immortalized human keratinocyte HaCaT cells. RJE suppressed both UVB-induced mitogen activated protein kinase (MAPK) and Akt signalling pathways as well as EGFR activity. RJE significantly suppressed repetitive UVB-induced wrinkle formation and COX-2 and MMP-13 expression in vivo. Among the compounds identified, syringic acid was found to exhibit the strongest inhibitory effect on UVB-induced MMP-1 promoter activity (45.2%). These results demonstrate that RJE has potent preventive activity for skin inflammation and photoaging which occurs via suppression of pathways related to EGFR.http://www.sciencedirect.com/science/article/pii/S1756464616303243Rhus javanica extract (RJE)InflammationPhotoagingCyclooxygenase-2 (COX-2)Matrix metalloproteinase-1 (MMP-1), mitogen-activated protein kinases (MAPKs), epidermal growth factor receptor (EGFR) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Su Jeong Ha Jangho Lee Hyojin Kim Kyung-Mo Song Nam Hyouck Lee Young Eon Kim Hookeun Lee Yong Ho Kim Sung Keun Jung |
spellingShingle |
Su Jeong Ha Jangho Lee Hyojin Kim Kyung-Mo Song Nam Hyouck Lee Young Eon Kim Hookeun Lee Yong Ho Kim Sung Keun Jung Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging Journal of Functional Foods Rhus javanica extract (RJE) Inflammation Photoaging Cyclooxygenase-2 (COX-2) Matrix metalloproteinase-1 (MMP-1), mitogen-activated protein kinases (MAPKs), epidermal growth factor receptor (EGFR) |
author_facet |
Su Jeong Ha Jangho Lee Hyojin Kim Kyung-Mo Song Nam Hyouck Lee Young Eon Kim Hookeun Lee Yong Ho Kim Sung Keun Jung |
author_sort |
Su Jeong Ha |
title |
Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging |
title_short |
Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging |
title_full |
Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging |
title_fullStr |
Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging |
title_full_unstemmed |
Preventive effect of Rhus javanica extract on UVB-induced skin inflammation and photoaging |
title_sort |
preventive effect of rhus javanica extract on uvb-induced skin inflammation and photoaging |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2016-12-01 |
description |
Rhus javanica has long been used in traditional medicines, and found to possess bioactive properties. In this study, we sought to investigate whether Rhus javanica extract (RJE) has preventive effects against UVB-induced inflammation and photoaging. RJE was identified as a promising candidate based on an MMP-1 promoter assay, and we confirmed suppressive effects on UVB-induced COX-2 and MMP-1 expression (67.6% and 80.9%, respectively) in immortalized human keratinocyte HaCaT cells. RJE suppressed both UVB-induced mitogen activated protein kinase (MAPK) and Akt signalling pathways as well as EGFR activity. RJE significantly suppressed repetitive UVB-induced wrinkle formation and COX-2 and MMP-13 expression in vivo. Among the compounds identified, syringic acid was found to exhibit the strongest inhibitory effect on UVB-induced MMP-1 promoter activity (45.2%). These results demonstrate that RJE has potent preventive activity for skin inflammation and photoaging which occurs via suppression of pathways related to EGFR. |
topic |
Rhus javanica extract (RJE) Inflammation Photoaging Cyclooxygenase-2 (COX-2) Matrix metalloproteinase-1 (MMP-1), mitogen-activated protein kinases (MAPKs), epidermal growth factor receptor (EGFR) |
url |
http://www.sciencedirect.com/science/article/pii/S1756464616303243 |
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