Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia
Background: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or...
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doaj-d588e39ea0124d3886c57701f219d5562020-11-25T02:32:24ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-10-011010.3389/fpsyt.2019.00756476573Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode SchizophreniaBei Zhang0Bei Zhang1Pan Lin2Xiaosheng Wang3Dost Öngür4Xinlei Ji5Weijun Situ6Shuqiao Yao7Xiang Wang8Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, ChinaGeneral and Experimental Psychology, Department of Psychology, LMU Munich, Munich, GermanyDepartment of Psychology and Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University, Changsha, ChinaDepartment of Human Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA, United StatesMedical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, ChinaBackground: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or structural characteristics leads to inconsistent findings in healthy adult and also schizophrenia. This study aims to develop an integrated striatal model and reveal the altered functional connectivity pattern of the striatum in schizophrenia.Methods: Two data-driven approaches, task-dependent meta-analytic connectivity modeling (MACM) and task-independent resting-state functional connectivity (RSFC), were used for seven anatomical connectivity-based striatum subregions to provide an integrated striatal model. Then, RSFC analyses of seven striatal subregions were applied to 45 first-episode schizophrenia (FES) and 27 healthy controls to examine the difference, based on the integrated model, of functional connectivity pattern of striatal subregions.Results: MACM and RSFC results showed that striatum subregions were associated with discrete cortical regions and involved in distinct cognitive processes. Besides, RSFC results overlapped with MACM findings but showed broader distributions. Importantly, significantly reduced functional connectivity was identified between limbic subregion and thalamus, medial prefrontal cortex, anterior cingulate cortex, and insula and also between executive subregions and thalamus, supplementary motor area, and insula in FES.Conclusions: Combing functional and structural connectivity information, this study provides the integrated model of corticostriatal subcircuits and confirms the abnormal functional connectivity of limbic and executive striatum subregions with different networks and thalamus, supporting the important role of the corticostriatal-thalamic loop in the pathophysiology of schizophrenia.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00756/fullstriatummeta-analytic connectivity modeling (MACM)resting-state functional connectivitycorticostriatal circuitsschizophrenia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bei Zhang Bei Zhang Pan Lin Xiaosheng Wang Dost Öngür Xinlei Ji Weijun Situ Shuqiao Yao Xiang Wang |
spellingShingle |
Bei Zhang Bei Zhang Pan Lin Xiaosheng Wang Dost Öngür Xinlei Ji Weijun Situ Shuqiao Yao Xiang Wang Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia Frontiers in Psychiatry striatum meta-analytic connectivity modeling (MACM) resting-state functional connectivity corticostriatal circuits schizophrenia |
author_facet |
Bei Zhang Bei Zhang Pan Lin Xiaosheng Wang Dost Öngür Xinlei Ji Weijun Situ Shuqiao Yao Xiang Wang |
author_sort |
Bei Zhang |
title |
Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_short |
Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_full |
Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_fullStr |
Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_full_unstemmed |
Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_sort |
altered functional connectivity of striatum based on the integrated connectivity model in first-episode schizophrenia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2019-10-01 |
description |
Background: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or structural characteristics leads to inconsistent findings in healthy adult and also schizophrenia. This study aims to develop an integrated striatal model and reveal the altered functional connectivity pattern of the striatum in schizophrenia.Methods: Two data-driven approaches, task-dependent meta-analytic connectivity modeling (MACM) and task-independent resting-state functional connectivity (RSFC), were used for seven anatomical connectivity-based striatum subregions to provide an integrated striatal model. Then, RSFC analyses of seven striatal subregions were applied to 45 first-episode schizophrenia (FES) and 27 healthy controls to examine the difference, based on the integrated model, of functional connectivity pattern of striatal subregions.Results: MACM and RSFC results showed that striatum subregions were associated with discrete cortical regions and involved in distinct cognitive processes. Besides, RSFC results overlapped with MACM findings but showed broader distributions. Importantly, significantly reduced functional connectivity was identified between limbic subregion and thalamus, medial prefrontal cortex, anterior cingulate cortex, and insula and also between executive subregions and thalamus, supplementary motor area, and insula in FES.Conclusions: Combing functional and structural connectivity information, this study provides the integrated model of corticostriatal subcircuits and confirms the abnormal functional connectivity of limbic and executive striatum subregions with different networks and thalamus, supporting the important role of the corticostriatal-thalamic loop in the pathophysiology of schizophrenia. |
topic |
striatum meta-analytic connectivity modeling (MACM) resting-state functional connectivity corticostriatal circuits schizophrenia |
url |
https://www.frontiersin.org/article/10.3389/fpsyt.2019.00756/full |
work_keys_str_mv |
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