Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway
Abstract Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and hearing loss. A Combination of cisplatin...
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doaj-d58a3f91f9b7434e85cbae1e0644bc922020-11-25T01:08:19ZengBMCJournal of Translational Medicine1479-58762018-04-0116111210.1186/s12967-018-1471-1Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathwayIman W. Achkar0Nabeel Abdulrahman1Hend Al-Sulaiti2Jensa Mariam Joseph3Shahab Uddin4Fatima Mraiche5Translational Research Institute, Hamad Medical CorporationCollege of Pharmacy, Qatar UniversityCollege of Pharmacy, Qatar UniversityCollege of Pharmacy, Qatar UniversityTranslational Research Institute, Hamad Medical CorporationCollege of Pharmacy, Qatar UniversityAbstract Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and hearing loss. A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity. The combination therapy also results in increased sensitivity of cisplatin towards cancer cells. The mitogen activated protein kinase (MAPK) pathway in the cell, consisting of extracellular signal regulated kinase, c-Jun N-terminal kinase, p38 kinases, and downstream mediator p90 ribosomal s6 kinase (RSK); is responsible for the regulation of various cellular events including cell survival, cell proliferation, cell cycle progression, cell migration and protein translation. This review article demonstrates the role of MAPK pathway in cisplatin based therapy, illustrates different combination therapy involving cisplatin and also shows the importance of targeting MAPK family, particularly RSK, to achieve increased anticancer effect and overcome drug resistance when combined with cisplatin.http://link.springer.com/article/10.1186/s12967-018-1471-1CisplatinMitogen activated protein kinasep90 ribosomal s6 kinaseCombination therapySynergyApoptosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Iman W. Achkar Nabeel Abdulrahman Hend Al-Sulaiti Jensa Mariam Joseph Shahab Uddin Fatima Mraiche |
spellingShingle |
Iman W. Achkar Nabeel Abdulrahman Hend Al-Sulaiti Jensa Mariam Joseph Shahab Uddin Fatima Mraiche Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway Journal of Translational Medicine Cisplatin Mitogen activated protein kinase p90 ribosomal s6 kinase Combination therapy Synergy Apoptosis |
author_facet |
Iman W. Achkar Nabeel Abdulrahman Hend Al-Sulaiti Jensa Mariam Joseph Shahab Uddin Fatima Mraiche |
author_sort |
Iman W. Achkar |
title |
Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway |
title_short |
Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway |
title_full |
Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway |
title_fullStr |
Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway |
title_full_unstemmed |
Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway |
title_sort |
cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway |
publisher |
BMC |
series |
Journal of Translational Medicine |
issn |
1479-5876 |
publishDate |
2018-04-01 |
description |
Abstract Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and hearing loss. A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity. The combination therapy also results in increased sensitivity of cisplatin towards cancer cells. The mitogen activated protein kinase (MAPK) pathway in the cell, consisting of extracellular signal regulated kinase, c-Jun N-terminal kinase, p38 kinases, and downstream mediator p90 ribosomal s6 kinase (RSK); is responsible for the regulation of various cellular events including cell survival, cell proliferation, cell cycle progression, cell migration and protein translation. This review article demonstrates the role of MAPK pathway in cisplatin based therapy, illustrates different combination therapy involving cisplatin and also shows the importance of targeting MAPK family, particularly RSK, to achieve increased anticancer effect and overcome drug resistance when combined with cisplatin. |
topic |
Cisplatin Mitogen activated protein kinase p90 ribosomal s6 kinase Combination therapy Synergy Apoptosis |
url |
http://link.springer.com/article/10.1186/s12967-018-1471-1 |
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