Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway

Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway

Abstract Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and hearing loss. A Combination of cisplatin...

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Bibliographic Details
Main Authors: Iman W. Achkar, Nabeel Abdulrahman, Hend Al-Sulaiti, Jensa Mariam Joseph, Shahab Uddin, Fatima Mraiche
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Translational Medicine
Subjects:
Cisplatin
Mitogen activated protein kinase
p90 ribosomal s6 kinase
Combination therapy
Synergy
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12967-018-1471-1

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