Physiological and Molecular Mechanisms of Methionine Restriction
Methionine restriction (MR) has been studied extensively over the last 25 years for its role in altering metabolic hallmarks of disease. Animals subjected to MR, display changes in metabolic flexibility demonstrated by increases in energy expenditure, glucose tolerance, and lifespan. These changes h...
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doaj-d58cc4e6e6224713bc3150c0b1da92262020-11-24T22:37:42ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-05-01910.3389/fendo.2018.00217365774Physiological and Molecular Mechanisms of Methionine RestrictionMary Neslund Latimer0Khalid Walid Freij1Beth M. Cleveland2Peggy R. Biga3Department of Biology, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, United StatesNational Center for Cool and Cold Water Aquaculture, Agricultural Research Service (USDA), Kearneysville, WV, United StatesDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, United StatesMethionine restriction (MR) has been studied extensively over the last 25 years for its role in altering metabolic hallmarks of disease. Animals subjected to MR, display changes in metabolic flexibility demonstrated by increases in energy expenditure, glucose tolerance, and lifespan. These changes have been well characterized in a number of model systems and significant progress has been made in understanding how hepatic fibroblast growth factor 21 links MR to several components of its metabolic phenotype. Despite these advances, a complete understanding of mechanisms engaged by dietary MR remains elusive. In this review, we offer a brief history of MR and its known mechanisms associated with stress, metabolism, and lifespan extension. We consider the role of epigenetics in the response of animals to MR and propose a novel epigenetic pathway involving the regulation of microRNAs during MR.http://journal.frontiersin.org/article/10.3389/fendo.2018.00217/fullmicroRNAmethionine restrictionstressphysiologicalcaloric restrictionmechanisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mary Neslund Latimer Khalid Walid Freij Beth M. Cleveland Peggy R. Biga |
spellingShingle |
Mary Neslund Latimer Khalid Walid Freij Beth M. Cleveland Peggy R. Biga Physiological and Molecular Mechanisms of Methionine Restriction Frontiers in Endocrinology microRNA methionine restriction stress physiological caloric restriction mechanisms |
author_facet |
Mary Neslund Latimer Khalid Walid Freij Beth M. Cleveland Peggy R. Biga |
author_sort |
Mary Neslund Latimer |
title |
Physiological and Molecular Mechanisms of Methionine Restriction |
title_short |
Physiological and Molecular Mechanisms of Methionine Restriction |
title_full |
Physiological and Molecular Mechanisms of Methionine Restriction |
title_fullStr |
Physiological and Molecular Mechanisms of Methionine Restriction |
title_full_unstemmed |
Physiological and Molecular Mechanisms of Methionine Restriction |
title_sort |
physiological and molecular mechanisms of methionine restriction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2018-05-01 |
description |
Methionine restriction (MR) has been studied extensively over the last 25 years for its role in altering metabolic hallmarks of disease. Animals subjected to MR, display changes in metabolic flexibility demonstrated by increases in energy expenditure, glucose tolerance, and lifespan. These changes have been well characterized in a number of model systems and significant progress has been made in understanding how hepatic fibroblast growth factor 21 links MR to several components of its metabolic phenotype. Despite these advances, a complete understanding of mechanisms engaged by dietary MR remains elusive. In this review, we offer a brief history of MR and its known mechanisms associated with stress, metabolism, and lifespan extension. We consider the role of epigenetics in the response of animals to MR and propose a novel epigenetic pathway involving the regulation of microRNAs during MR. |
topic |
microRNA methionine restriction stress physiological caloric restriction mechanisms |
url |
http://journal.frontiersin.org/article/10.3389/fendo.2018.00217/full |
work_keys_str_mv |
AT maryneslundlatimer physiologicalandmolecularmechanismsofmethioninerestriction AT khalidwalidfreij physiologicalandmolecularmechanismsofmethioninerestriction AT bethmcleveland physiologicalandmolecularmechanismsofmethioninerestriction AT peggyrbiga physiologicalandmolecularmechanismsofmethioninerestriction |
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1725715933364748288 |