Seek the Spindle Tumor in Submandibular Space
Introduction: Submandibular region is surgically significant in the head and neck field and a mass in this region may have multiple differential diagnoses. Case Report: An elderly man came with a single 4×2.5 cm swelling in the neck on the right side, just below the lower jaw, since one month. Ult...
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doaj-d5918c3e6ba744df970a0a4461e7baef2020-11-25T02:45:47ZengMashhad University of Medical SciencesIranian Journal of Otorhinolaryngology2251-72512251-726X2019-05-0131318118410.22038/ijorl.2019.28427.193112714Seek the Spindle Tumor in Submandibular SpaceDeviprasad Dosemane0Urmila Khadilkar1Meera Khadilkar2Fayis Anwar3Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education. India.Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education. India.Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education. India.Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education. India.Introduction: Submandibular region is surgically significant in the head and neck field and a mass in this region may have multiple differential diagnoses. Case Report: An elderly man came with a single 4×2.5 cm swelling in the neck on the right side, just below the lower jaw, since one month. Ultrasound showed an irregular heterogeneous hypoechoic lesion in the right submandibular space measuring 37×23 mm with mild internal vascularity. The submandibular gland appeared separate but compressed. Fine needle aspiration was suggestive of spindle cell neoplasm. The swelling was excised under general anesthesia. By histopathological examination, the lesion was diagnosed as anaplastic lymphoma kinase-negative inflammatory myofibroblastic tumor (IMT) based on focal immunoreactivity with cyclin D1. The patient then received radiotherapy 60 Gray divided into 30 fractions over 6 weeks. The case had no evidence of recurrence or residual disease six months post-surgery. Conclusion: Tumefactive spindle-cell lesion in the head and neck can comprise inflammatory conditions, benign and malignant neoplasms or borderline neoplasms, such as nodular fasciitis and IMT. The definitive histologic diagnosis of IMT helps in tailoring the treatment modality based on its locally aggressive biologic potential.http://ijorl.mums.ac.ir/article_12714_536123fcce9233efbb43837336b31638.pdfimmunohistochemistryInflammatory myofibroblastic tumorSpindle neoplasmSubmandibular |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Deviprasad Dosemane Urmila Khadilkar Meera Khadilkar Fayis Anwar |
spellingShingle |
Deviprasad Dosemane Urmila Khadilkar Meera Khadilkar Fayis Anwar Seek the Spindle Tumor in Submandibular Space Iranian Journal of Otorhinolaryngology immunohistochemistry Inflammatory myofibroblastic tumor Spindle neoplasm Submandibular |
author_facet |
Deviprasad Dosemane Urmila Khadilkar Meera Khadilkar Fayis Anwar |
author_sort |
Deviprasad Dosemane |
title |
Seek the Spindle Tumor in Submandibular Space |
title_short |
Seek the Spindle Tumor in Submandibular Space |
title_full |
Seek the Spindle Tumor in Submandibular Space |
title_fullStr |
Seek the Spindle Tumor in Submandibular Space |
title_full_unstemmed |
Seek the Spindle Tumor in Submandibular Space |
title_sort |
seek the spindle tumor in submandibular space |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Otorhinolaryngology |
issn |
2251-7251 2251-726X |
publishDate |
2019-05-01 |
description |
Introduction: Submandibular region is surgically significant in the head and neck field and a mass in this region may have multiple differential diagnoses. Case Report: An elderly man came with a single 4×2.5 cm swelling in the neck on the right side, just below the lower jaw, since one month. Ultrasound showed an irregular heterogeneous hypoechoic lesion in the right submandibular space measuring 37×23 mm with mild internal vascularity. The submandibular gland appeared separate but compressed. Fine needle aspiration was suggestive of spindle cell neoplasm. The swelling was excised under general anesthesia. By histopathological examination, the lesion was diagnosed as anaplastic lymphoma kinase-negative inflammatory myofibroblastic tumor (IMT) based on focal immunoreactivity with cyclin D1. The patient then received radiotherapy 60 Gray divided into 30 fractions over 6 weeks. The case had no evidence of recurrence or residual disease six months post-surgery. Conclusion: Tumefactive spindle-cell lesion in the head and neck can comprise inflammatory conditions, benign and malignant neoplasms or borderline neoplasms, such as nodular fasciitis and IMT. The definitive histologic diagnosis of IMT helps in tailoring the treatment modality based on its locally aggressive biologic potential. |
topic |
immunohistochemistry Inflammatory myofibroblastic tumor Spindle neoplasm Submandibular |
url |
http://ijorl.mums.ac.ir/article_12714_536123fcce9233efbb43837336b31638.pdf |
work_keys_str_mv |
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