Activity of 9-acridanone-hydrazone drugs detected at the pre-postural phase, in the experimental schistosomiasis mansoni

• Main Authors: Leogenes Horacio Pereira, Paulo Marcos Zech Coelho, Jose Oswaldo Costa, Rômulo Teixeira de Mello
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1995-06-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: acridanone-hydrazones; Schistosoma mansoni; experimental shchistosomiasis
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000300021

The compound Ro-15.5458/000, derivative in the class of 9-acridanone-hydrazones, was found to be effective against Schistosoma mansoni in mice, killing almost all the skin schistosomules (24 hr after infection), when administered at the dose of 100 mg/kg. In experiments carried out with Cebus monkeys, the drug was shown to be fully effective at 25 mg/kg, 7 days after infection. These data, associated with the good results obtained earlier at the post-postural phase of schistosomiasis, allow the inference that this promising compound may be important in the set of antischistosomal drugs, depending on further toxicological and clinical tests.