Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
Abstract Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for...
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2018-02-01
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Online Access: | https://doi.org/10.1038/s41598-018-21421-x |
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doaj-d592d012eaf440e78649dd72c1c0a8512020-12-08T04:52:58ZengNature Publishing GroupScientific Reports2045-23222018-02-01811710.1038/s41598-018-21421-xHypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO miceBaiqiang Zhai0Chuanhai Zhang1Yao Sheng2Changhui Zhao3Xiaoyun He4Wentao Xu5Kunlun Huang6Yunbo Luo7Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityDepartment of Food Quality and Safety, College of Food Science and Engineering, Jilin UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityAbstract Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for 8 weeks. Results showed that alliin had no significant effect on the body weight, adiposity or energy balance. However, alliin treatment enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile in the DIO mice. This was, at least partly, attributable to alliin induced modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae. From above, we conclude that alliin has nutraceutical or even medicinal potential in prevention of diabetes and lipid metabolic disorders.https://doi.org/10.1038/s41598-018-21421-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Baiqiang Zhai Chuanhai Zhang Yao Sheng Changhui Zhao Xiaoyun He Wentao Xu Kunlun Huang Yunbo Luo |
spellingShingle |
Baiqiang Zhai Chuanhai Zhang Yao Sheng Changhui Zhao Xiaoyun He Wentao Xu Kunlun Huang Yunbo Luo Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice Scientific Reports |
author_facet |
Baiqiang Zhai Chuanhai Zhang Yao Sheng Changhui Zhao Xiaoyun He Wentao Xu Kunlun Huang Yunbo Luo |
author_sort |
Baiqiang Zhai |
title |
Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice |
title_short |
Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice |
title_full |
Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice |
title_fullStr |
Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice |
title_full_unstemmed |
Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice |
title_sort |
hypoglycemic and hypolipidemic effect of s-allyl-cysteine sulfoxide (alliin) in dio mice |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2018-02-01 |
description |
Abstract Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for 8 weeks. Results showed that alliin had no significant effect on the body weight, adiposity or energy balance. However, alliin treatment enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile in the DIO mice. This was, at least partly, attributable to alliin induced modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae. From above, we conclude that alliin has nutraceutical or even medicinal potential in prevention of diabetes and lipid metabolic disorders. |
url |
https://doi.org/10.1038/s41598-018-21421-x |
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