The effect of listening to music on human transcriptome
Although brain imaging studies have demonstrated that listening to music alters human brain structure and function, the molecular mechanisms mediating those effects remain unknown. With the advent of genomics and bioinformatics approaches, these effects of music can now be studied in a more detailed...
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doaj-d593c626c7ef4aa1bca42d63d3f0a4832020-11-24T22:39:51ZengPeerJ Inc.PeerJ2167-83592015-03-013e83010.7717/peerj.830830The effect of listening to music on human transcriptomeChakravarthi Kanduri0Pirre Raijas1Minna Ahvenainen2Anju K. Philips3Liisa Ukkola-Vuoti4Harri Lähdesmäki5Irma Järvelä6Department of Medical Genetics, University of Helsinki, FinlandDocMus Department, University of the Arts Helsinki, Helsinki, FinlandDepartment of Medical Genetics, University of Helsinki, FinlandDepartment of Medical Genetics, University of Helsinki, FinlandDepartment of Medical Genetics, University of Helsinki, FinlandDepartment of Information and Computer Science, Aalto University, AALTO, FinlandDepartment of Medical Genetics, University of Helsinki, FinlandAlthough brain imaging studies have demonstrated that listening to music alters human brain structure and function, the molecular mechanisms mediating those effects remain unknown. With the advent of genomics and bioinformatics approaches, these effects of music can now be studied in a more detailed fashion. To verify whether listening to classical music has any effect on human transcriptome, we performed genome-wide transcriptional profiling from the peripheral blood of participants after listening to classical music (n = 48), and after a control study without music exposure (n = 15). As musical experience is known to influence the responses to music, we compared the transcriptional responses of musically experienced and inexperienced participants separately with those of the controls. Comparisons were made based on two subphenotypes of musical experience: musical aptitude and music education. In musically experiencd participants, we observed the differential expression of 45 genes (27 up- and 18 down-regulated) and 97 genes (75 up- and 22 down-regulated) respectively based on subphenotype comparisons (rank product non-parametric statistics, pfp 0.05, >1.2-fold change over time across conditions). Gene ontological overrepresentation analysis (hypergeometric test, FDR < 0.05) revealed that the up-regulated genes are primarily known to be involved in the secretion and transport of dopamine, neuron projection, protein sumoylation, long-term potentiation and dephosphorylation. Down-regulated genes are known to be involved in ATP synthase-coupled proton transport, cytolysis, and positive regulation of caspase, peptidase and endopeptidase activities. One of the most up-regulated genes, alpha-synuclein (SNCA), is located in the best linkage region of musical aptitude on chromosome 4q22.1 and is regulated by GATA2, which is known to be associated with musical aptitude. Several genes reported to regulate song perception and production in songbirds displayed altered activities, suggesting a possible evolutionary conservation of sound perception between species. We observed no significant findings in musically inexperienced participants.https://peerj.com/articles/830.pdfMusicRNAGene expression profilingDopamineLong-term potentiationGenomics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chakravarthi Kanduri Pirre Raijas Minna Ahvenainen Anju K. Philips Liisa Ukkola-Vuoti Harri Lähdesmäki Irma Järvelä |
spellingShingle |
Chakravarthi Kanduri Pirre Raijas Minna Ahvenainen Anju K. Philips Liisa Ukkola-Vuoti Harri Lähdesmäki Irma Järvelä The effect of listening to music on human transcriptome PeerJ Music RNA Gene expression profiling Dopamine Long-term potentiation Genomics |
author_facet |
Chakravarthi Kanduri Pirre Raijas Minna Ahvenainen Anju K. Philips Liisa Ukkola-Vuoti Harri Lähdesmäki Irma Järvelä |
author_sort |
Chakravarthi Kanduri |
title |
The effect of listening to music on human transcriptome |
title_short |
The effect of listening to music on human transcriptome |
title_full |
The effect of listening to music on human transcriptome |
title_fullStr |
The effect of listening to music on human transcriptome |
title_full_unstemmed |
The effect of listening to music on human transcriptome |
title_sort |
effect of listening to music on human transcriptome |
publisher |
PeerJ Inc. |
series |
PeerJ |
issn |
2167-8359 |
publishDate |
2015-03-01 |
description |
Although brain imaging studies have demonstrated that listening to music alters human brain structure and function, the molecular mechanisms mediating those effects remain unknown. With the advent of genomics and bioinformatics approaches, these effects of music can now be studied in a more detailed fashion. To verify whether listening to classical music has any effect on human transcriptome, we performed genome-wide transcriptional profiling from the peripheral blood of participants after listening to classical music (n = 48), and after a control study without music exposure (n = 15). As musical experience is known to influence the responses to music, we compared the transcriptional responses of musically experienced and inexperienced participants separately with those of the controls. Comparisons were made based on two subphenotypes of musical experience: musical aptitude and music education. In musically experiencd participants, we observed the differential expression of 45 genes (27 up- and 18 down-regulated) and 97 genes (75 up- and 22 down-regulated) respectively based on subphenotype comparisons (rank product non-parametric statistics, pfp 0.05, >1.2-fold change over time across conditions). Gene ontological overrepresentation analysis (hypergeometric test, FDR < 0.05) revealed that the up-regulated genes are primarily known to be involved in the secretion and transport of dopamine, neuron projection, protein sumoylation, long-term potentiation and dephosphorylation. Down-regulated genes are known to be involved in ATP synthase-coupled proton transport, cytolysis, and positive regulation of caspase, peptidase and endopeptidase activities. One of the most up-regulated genes, alpha-synuclein (SNCA), is located in the best linkage region of musical aptitude on chromosome 4q22.1 and is regulated by GATA2, which is known to be associated with musical aptitude. Several genes reported to regulate song perception and production in songbirds displayed altered activities, suggesting a possible evolutionary conservation of sound perception between species. We observed no significant findings in musically inexperienced participants. |
topic |
Music RNA Gene expression profiling Dopamine Long-term potentiation Genomics |
url |
https://peerj.com/articles/830.pdf |
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