Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health
Several scalp microbiome studies from different populations have revealed the association of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of...
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doaj-d5a33eeda467437e9346679882e13cde2020-11-24T22:48:08ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882018-10-01810.3389/fcimb.2018.00346406709Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp HealthRituja Saxena0Parul Mittal1Cecile Clavaud2Darshan B. Dhakan3Prashant Hegde4Mahesh M. Veeranagaiah5Subarna Saha6Luc Souverain7Nita Roy8Lionel Breton9Namita Misra10Namita Misra11Vineet K. Sharma12Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, IndiaDepartment of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, IndiaL'Oréal Research & Innovation, Aulnay-sous-Bois, FranceDepartment of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, IndiaL'Oréal India Pvt. Ltd., Bengaluru, IndiaL'Oréal India Pvt. Ltd., Bengaluru, IndiaL'Oréal India Pvt. Ltd., Bengaluru, IndiaL'Oréal Research & Innovation, Aulnay-sous-Bois, FranceL'Oréal India Pvt. Ltd., Bengaluru, IndiaL'Oréal Research & Innovation, Aulnay-sous-Bois, FranceL'Oréal Research & Innovation, Aulnay-sous-Bois, FranceL'Oréal India Pvt. Ltd., Bengaluru, IndiaDepartment of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, IndiaSeveral scalp microbiome studies from different populations have revealed the association of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of dandruff.https://www.frontiersin.org/article/10.3389/fcimb.2018.00346/fullscalp microbiomemetagenomicsdandruffbiotinB-vitaminsMalassezia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rituja Saxena Parul Mittal Cecile Clavaud Darshan B. Dhakan Prashant Hegde Mahesh M. Veeranagaiah Subarna Saha Luc Souverain Nita Roy Lionel Breton Namita Misra Namita Misra Vineet K. Sharma |
spellingShingle |
Rituja Saxena Parul Mittal Cecile Clavaud Darshan B. Dhakan Prashant Hegde Mahesh M. Veeranagaiah Subarna Saha Luc Souverain Nita Roy Lionel Breton Namita Misra Namita Misra Vineet K. Sharma Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health Frontiers in Cellular and Infection Microbiology scalp microbiome metagenomics dandruff biotin B-vitamins Malassezia |
author_facet |
Rituja Saxena Parul Mittal Cecile Clavaud Darshan B. Dhakan Prashant Hegde Mahesh M. Veeranagaiah Subarna Saha Luc Souverain Nita Roy Lionel Breton Namita Misra Namita Misra Vineet K. Sharma |
author_sort |
Rituja Saxena |
title |
Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health |
title_short |
Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health |
title_full |
Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health |
title_fullStr |
Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health |
title_full_unstemmed |
Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health |
title_sort |
comparison of healthy and dandruff scalp microbiome reveals the role of commensals in scalp health |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2018-10-01 |
description |
Several scalp microbiome studies from different populations have revealed the association of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of dandruff. |
topic |
scalp microbiome metagenomics dandruff biotin B-vitamins Malassezia |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2018.00346/full |
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