Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy

Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy

We report a case of anti-HMGCR myopathy mimicking limb-girdle muscular dystrophy in a 27-year-old male patient with no history of statin intake and presenting with a chronic onset form over 3 years. Treatment with prednisone and methotrexate was initiated with an insufficient response, so intravenou...

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Main Authors: Noel Lorenzo Villalba, Emmanuel Andrés, Alain Meyer
Format: Article
Language:English
Published: SMC MEDIA SRL 2021-06-01
Series:European Journal of Case Reports in Internal Medicine
Online Access:https://www.ejcrim.com/index.php/EJCRIM/article/view/2672
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spelling doaj-d5a874346f7b4f559fccb83316447ffe2021-07-08T07:42:22ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942021-06-0110.12890/2021_0026722288Chronic Onset Form of Anti-HMG-CoA Reductase MyopathyNoel Lorenzo Villalba0Emmanuel Andrés1Alain Meyer2Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasboug, FranceService de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasboug, FranceService de Rhumatologie, Hôpitaux Universitaires de Strasbourg, FranceWe report a case of anti-HMGCR myopathy mimicking limb-girdle muscular dystrophy in a 27-year-old male patient with no history of statin intake and presenting with a chronic onset form over 3 years. Treatment with prednisone and methotrexate was initiated with an insufficient response, so intravenous immunoglobulin was added. One year after initial treatment was started, as levels of creatine kinase (CK) were >1000 U/l, treatment with rituximab was added. Despite a 3-year delay before treatment, muscle strength improved even though CK levels remain elevated.https://www.ejcrim.com/index.php/EJCRIM/article/view/2672
collection DOAJ
language English
format Article
sources DOAJ
author Noel Lorenzo Villalba
Emmanuel Andrés
Alain Meyer
spellingShingle Noel Lorenzo Villalba
Emmanuel Andrés
Alain Meyer
Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
European Journal of Case Reports in Internal Medicine
author_facet Noel Lorenzo Villalba
Emmanuel Andrés
Alain Meyer
author_sort Noel Lorenzo Villalba
title Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
title_short Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
title_full Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
title_fullStr Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
title_full_unstemmed Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
title_sort chronic onset form of anti-hmg-coa reductase myopathy
publisher SMC MEDIA SRL
series European Journal of Case Reports in Internal Medicine
issn 2284-2594
publishDate 2021-06-01
description We report a case of anti-HMGCR myopathy mimicking limb-girdle muscular dystrophy in a 27-year-old male patient with no history of statin intake and presenting with a chronic onset form over 3 years. Treatment with prednisone and methotrexate was initiated with an insufficient response, so intravenous immunoglobulin was added. One year after initial treatment was started, as levels of creatine kinase (CK) were >1000 U/l, treatment with rituximab was added. Despite a 3-year delay before treatment, muscle strength improved even though CK levels remain elevated.
url https://www.ejcrim.com/index.php/EJCRIM/article/view/2672
work_keys_str_mv AT noellorenzovillalba chroniconsetformofantihmgcoareductasemyopathy
AT emmanuelandres chroniconsetformofantihmgcoareductasemyopathy
AT alainmeyer chroniconsetformofantihmgcoareductasemyopathy
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