Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration

Following epithelial-mesenchymal transition, avian trunk neural crest cell polarity determines directional migration but how this is established is unclear. Here, the authors find that the RhoGAP, Deleted in liver cancer 1, is asymmetrically localized in the cytoplasm, governing neural crest migrato...

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Main Authors:	Jessica Aijia Liu, Yanxia Rao, May Pui Lai Cheung, Man-Ning Hui, Ming-Hoi Wu, Lo-Kong Chan, Irene Oi-Lin Ng, Ben Niu, Kathryn S. E. Cheah, Rakesh Sharma, Louis Hodgson, Martin Cheung
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01107-0

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spelling	doaj-d5afe614c7da4570bdef1328892dfbb02021-05-11T07:11:49ZengNature Publishing GroupNature Communications2041-17232017-10-018111710.1038/s41467-017-01107-0Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migrationJessica Aijia Liu0Yanxia Rao1May Pui Lai Cheung2Man-Ning Hui3Ming-Hoi Wu4Lo-Kong Chan5Irene Oi-Lin Ng6Ben Niu7Kathryn S. E. Cheah8Rakesh Sharma9Louis Hodgson10Martin Cheung11School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, The University of Hong KongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong KongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongProteomics and Metabolomics Core Facility, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Anatomy and Structural Biology, Gruss-Lipper Biophotonics Center, Albert Einstein College of MedicineSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongFollowing epithelial-mesenchymal transition, avian trunk neural crest cell polarity determines directional migration but how this is established is unclear. Here, the authors find that the RhoGAP, Deleted in liver cancer 1, is asymmetrically localized in the cytoplasm, governing neural crest migratory polarization.https://doi.org/10.1038/s41467-017-01107-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jessica Aijia Liu Yanxia Rao May Pui Lai Cheung Man-Ning Hui Ming-Hoi Wu Lo-Kong Chan Irene Oi-Lin Ng Ben Niu Kathryn S. E. Cheah Rakesh Sharma Louis Hodgson Martin Cheung
spellingShingle	Jessica Aijia Liu Yanxia Rao May Pui Lai Cheung Man-Ning Hui Ming-Hoi Wu Lo-Kong Chan Irene Oi-Lin Ng Ben Niu Kathryn S. E. Cheah Rakesh Sharma Louis Hodgson Martin Cheung Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration Nature Communications
author_facet	Jessica Aijia Liu Yanxia Rao May Pui Lai Cheung Man-Ning Hui Ming-Hoi Wu Lo-Kong Chan Irene Oi-Lin Ng Ben Niu Kathryn S. E. Cheah Rakesh Sharma Louis Hodgson Martin Cheung
author_sort	Jessica Aijia Liu
title	Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration
title_short	Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration
title_full	Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration
title_fullStr	Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration
title_full_unstemmed	Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration
title_sort	asymmetric localization of dlc1 defines avian trunk neural crest polarity for directional delamination and migration
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	Following epithelial-mesenchymal transition, avian trunk neural crest cell polarity determines directional migration but how this is established is unclear. Here, the authors find that the RhoGAP, Deleted in liver cancer 1, is asymmetrically localized in the cytoplasm, governing neural crest migratory polarization.
url	https://doi.org/10.1038/s41467-017-01107-0
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Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration

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