Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway

Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway

Sinulariolide, an active compound isolated from the cultured soft coral Sinularia flexibilis, has potent anti-microbial and anti-tumorigenesis effects towards melanoma and bladder cancer cells. In this study, we investigated the effects of sinulariolide on hepatocellular carcinoma (HCC) cell growth...

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Bibliographic Details
Main Authors: Yu-Jen Wu, Shun-Hsiang Weng, Han Hisang Huang, Feng-Jen Tsai, Zih-Yan Yang, Ming-Hui Liao, Chun-Tzu Hung, Jen-Jie Lin, Hsiang-Hao Chao, Chia-Yu Tsao, Yi-Jen Chen, Jui-Hsin Su
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Molecules
Subjects:
hepatocellular carcinoma
sinulariolide
mitochondrial
PERK/eIF2α/ATF4/CHOP
apoptosis
Online Access:http://www.mdpi.com/1420-3049/18/9/10146

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