Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.
<h4>Background</h4>Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI).<h4>Aim</h4>To confirm the association between the MHC2TA -168A-->G polymorphism...
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doaj-d5b4e4c340dc4dc780bbe5e9e6a274cb2021-03-03T22:30:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032006-12-011e6410.1371/journal.pone.0000064Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.Eero LindholmOlle MelanderPeter AlmgrenGöran BerglundCarl-David AgardhLeif GroopMarju Orho-Melander<h4>Background</h4>Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI).<h4>Aim</h4>To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality.<h4>Materials and methods</h4>Using an allelic discrimination method we genotyped 11,064 individuals from three study populations: 1) 4,432 individuals from the Botnia type 2 diabetes (T2D) study, 2) 1,222 patients with MI and 2,345 control subjects participating in the Malmö Diet and Cancer study and comprising an MI case-control sample, and 3) 3,065 T2D patients from the Local Swedish Diabetes registry.<h4>Results</h4>No association between the -168A-->G polymorphism in MHC2TA and MI was observed. However, in the Botnia cohort the AG/GG genotypes were associated with cardiovascular mortality after MI (1.78 [1.09-2.92], p = 0.02). In addition, the AG/GG genotypes were more common in subjects with MetS (40.1% vs. 36.9%, p = 0.03) and in non-diabetic subjects with microalbuminuria (45.4% vs. 36.5%, p = 0.003) compared to control subjects.<h4>Conclusions</h4>A polymorphism in MHC2TA was associated with cardiovascular mortality and predictors of cardiovascular mortality, microalbuminuria and MetS.https://doi.org/10.1371/journal.pone.0000064 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eero Lindholm Olle Melander Peter Almgren Göran Berglund Carl-David Agardh Leif Groop Marju Orho-Melander |
spellingShingle |
Eero Lindholm Olle Melander Peter Almgren Göran Berglund Carl-David Agardh Leif Groop Marju Orho-Melander Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. PLoS ONE |
author_facet |
Eero Lindholm Olle Melander Peter Almgren Göran Berglund Carl-David Agardh Leif Groop Marju Orho-Melander |
author_sort |
Eero Lindholm |
title |
Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. |
title_short |
Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. |
title_full |
Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. |
title_fullStr |
Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. |
title_full_unstemmed |
Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. |
title_sort |
polymorphism in the mhc2ta gene is associated with features of the metabolic syndrome and cardiovascular mortality. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2006-12-01 |
description |
<h4>Background</h4>Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI).<h4>Aim</h4>To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality.<h4>Materials and methods</h4>Using an allelic discrimination method we genotyped 11,064 individuals from three study populations: 1) 4,432 individuals from the Botnia type 2 diabetes (T2D) study, 2) 1,222 patients with MI and 2,345 control subjects participating in the Malmö Diet and Cancer study and comprising an MI case-control sample, and 3) 3,065 T2D patients from the Local Swedish Diabetes registry.<h4>Results</h4>No association between the -168A-->G polymorphism in MHC2TA and MI was observed. However, in the Botnia cohort the AG/GG genotypes were associated with cardiovascular mortality after MI (1.78 [1.09-2.92], p = 0.02). In addition, the AG/GG genotypes were more common in subjects with MetS (40.1% vs. 36.9%, p = 0.03) and in non-diabetic subjects with microalbuminuria (45.4% vs. 36.5%, p = 0.003) compared to control subjects.<h4>Conclusions</h4>A polymorphism in MHC2TA was associated with cardiovascular mortality and predictors of cardiovascular mortality, microalbuminuria and MetS. |
url |
https://doi.org/10.1371/journal.pone.0000064 |
work_keys_str_mv |
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