Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring
Cancer is a leading cause of death worldwide and actual analytical techniques are restrictive in detecting it. Thus, there is still a challenge, as well as a need, for the development of quantitative non-invasive tools for the diagnosis of cancers and the follow-up care of patients. We introduce fir...
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doaj-d5c78b6f9661420aaad8d69d81babd2b2020-11-24T21:49:11ZengMDPI AGSensors1424-82202016-06-0116691510.3390/s16060915s16060915Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer MonitoringCorinne Dejous0Hamida Hallil1Vincent Raimbault2Jean-Luc Lachaud3Bernard Plano4Raphaël Delépée5Patrick Favetta6Luigi Agrofoglio7Dominique Rebière8IMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, FranceIMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, FranceIMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, FranceIMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, FranceIMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, FranceNormandie Univ., UNICAEN, UNIROUEN, ABTE, 14000 Caen, FranceICOA, University Orléans, CNRS, CNRS UMR 7311, F-45067 Orléans, FranceICOA, University Orléans, CNRS, CNRS UMR 7311, F-45067 Orléans, FranceIMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, FranceCancer is a leading cause of death worldwide and actual analytical techniques are restrictive in detecting it. Thus, there is still a challenge, as well as a need, for the development of quantitative non-invasive tools for the diagnosis of cancers and the follow-up care of patients. We introduce first the overall interest of electronic nose or tongue for such application of microsensors arrays with data processing in complex media, either gas (e.g., Volatile Organic Compounds or VOCs as biomarkers in breath) or liquid (e.g., modified nucleosides as urinary biomarkers). Then this is illustrated with a versatile acoustic wave transducer, functionalized with molecularly-imprinted polymers (MIP) synthesized for adenosine-5′-monophosphate (AMP) as a model for nucleosides. The device including the thin film coating is described, then static measurements with scanning electron microscopy (SEM) and electrical characterization after each step of the sensitive MIP process (deposit, removal of AMP template, capture of AMP target) demonstrate the thin film functionality. Dynamic measurements with a microfluidic setup and four targets are presented afterwards. They show a sensitivity of 5 Hz·ppm−1 of the non-optimized microsensor for AMP detection, with a specificity of three times compared to PMPA, and almost nil sensitivity to 3′AMP and CMP, in accordance with previously published results on bulk MIP.http://www.mdpi.com/1424-8220/16/6/915chemical sensorsurface acoustic waveMIPnucleosidecancer biomarkerurinarymicrofluidicelectronic tongue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Corinne Dejous Hamida Hallil Vincent Raimbault Jean-Luc Lachaud Bernard Plano Raphaël Delépée Patrick Favetta Luigi Agrofoglio Dominique Rebière |
spellingShingle |
Corinne Dejous Hamida Hallil Vincent Raimbault Jean-Luc Lachaud Bernard Plano Raphaël Delépée Patrick Favetta Luigi Agrofoglio Dominique Rebière Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring Sensors chemical sensor surface acoustic wave MIP nucleoside cancer biomarker urinary microfluidic electronic tongue |
author_facet |
Corinne Dejous Hamida Hallil Vincent Raimbault Jean-Luc Lachaud Bernard Plano Raphaël Delépée Patrick Favetta Luigi Agrofoglio Dominique Rebière |
author_sort |
Corinne Dejous |
title |
Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring |
title_short |
Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring |
title_full |
Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring |
title_fullStr |
Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring |
title_full_unstemmed |
Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring |
title_sort |
love acoustic wave-based devices and molecularly-imprinted polymers as versatile sensors for electronic nose or tongue for cancer monitoring |
publisher |
MDPI AG |
series |
Sensors |
issn |
1424-8220 |
publishDate |
2016-06-01 |
description |
Cancer is a leading cause of death worldwide and actual analytical techniques are restrictive in detecting it. Thus, there is still a challenge, as well as a need, for the development of quantitative non-invasive tools for the diagnosis of cancers and the follow-up care of patients. We introduce first the overall interest of electronic nose or tongue for such application of microsensors arrays with data processing in complex media, either gas (e.g., Volatile Organic Compounds or VOCs as biomarkers in breath) or liquid (e.g., modified nucleosides as urinary biomarkers). Then this is illustrated with a versatile acoustic wave transducer, functionalized with molecularly-imprinted polymers (MIP) synthesized for adenosine-5′-monophosphate (AMP) as a model for nucleosides. The device including the thin film coating is described, then static measurements with scanning electron microscopy (SEM) and electrical characterization after each step of the sensitive MIP process (deposit, removal of AMP template, capture of AMP target) demonstrate the thin film functionality. Dynamic measurements with a microfluidic setup and four targets are presented afterwards. They show a sensitivity of 5 Hz·ppm−1 of the non-optimized microsensor for AMP detection, with a specificity of three times compared to PMPA, and almost nil sensitivity to 3′AMP and CMP, in accordance with previously published results on bulk MIP. |
topic |
chemical sensor surface acoustic wave MIP nucleoside cancer biomarker urinary microfluidic electronic tongue |
url |
http://www.mdpi.com/1424-8220/16/6/915 |
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