Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia

Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia

A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids – N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine – were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, co...

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Main Authors: Kazumasa Zaima, Marc Litaudon, Azeana Zahari, Hazrina Hazni, A Hamid A Hadi, Khalijah Awang, Mat Ropi Mukhtar, Syazreen Nadia Sulaiman, Hiroshi Morita
Format: Article
Language:English
Published: MDPI AG 2011-04-01
Series:Molecules
Subjects:
bisbenzylisoquinoline
lancifoliaine
N-allyllaurolitsine
Lauraceae
vaso-relaxant activity
Online Access:http://www.mdpi.com/1420-3049/16/4/3119/
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spelling doaj-d5c9c7f008e3464fb13a40deb67abe862020-11-25T00:27:28ZengMDPI AGMolecules1420-30492011-04-011643119312710.3390/molecules16043119Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifoliaKazumasa ZaimaMarc LitaudonAzeana ZahariHazrina HazniA Hamid A HadiKhalijah AwangMat Ropi MukhtarSyazreen Nadia SulaimanHiroshi MoritaA new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids – N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine – were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, complete 13C-NMR data of N-allyl-laurolitsine (2) was also reported. The alkaloidal structures were elucidated by means of high field 1D- and 2D-NMR IR, UV, and LCMS-IT-TOF spectral data. N-Allyllaurolitsine (2) showed a moderate vasorelaxant activity on isolated rat aorta. http://www.mdpi.com/1420-3049/16/4/3119/bisbenzylisoquinolinelancifoliaineN-allyllaurolitsineLauraceaevaso-relaxant activity
collection DOAJ
language English
format Article
sources DOAJ
author Kazumasa Zaima
Marc Litaudon
Azeana Zahari
Hazrina Hazni
A Hamid A Hadi
Khalijah Awang
Mat Ropi Mukhtar
Syazreen Nadia Sulaiman
Hiroshi Morita
spellingShingle Kazumasa Zaima
Marc Litaudon
Azeana Zahari
Hazrina Hazni
A Hamid A Hadi
Khalijah Awang
Mat Ropi Mukhtar
Syazreen Nadia Sulaiman
Hiroshi Morita
Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia
Molecules
bisbenzylisoquinoline
lancifoliaine
N-allyllaurolitsine
Lauraceae
vaso-relaxant activity
author_facet Kazumasa Zaima
Marc Litaudon
Azeana Zahari
Hazrina Hazni
A Hamid A Hadi
Khalijah Awang
Mat Ropi Mukhtar
Syazreen Nadia Sulaiman
Hiroshi Morita
author_sort Kazumasa Zaima
title Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia
title_short Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia
title_full Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia
title_fullStr Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia
title_full_unstemmed Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia
title_sort lancifoliaine, a new bisbenzylisoquinoline from the bark of litsea lancifolia
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2011-04-01
description A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids – N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine – were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, complete 13C-NMR data of N-allyl-laurolitsine (2) was also reported. The alkaloidal structures were elucidated by means of high field 1D- and 2D-NMR IR, UV, and LCMS-IT-TOF spectral data. N-Allyllaurolitsine (2) showed a moderate vasorelaxant activity on isolated rat aorta.
topic bisbenzylisoquinoline
lancifoliaine
N-allyllaurolitsine
Lauraceae
vaso-relaxant activity
url http://www.mdpi.com/1420-3049/16/4/3119/
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