Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy
Background. Chemerin is a chemokine known to be increased in morbidly obese (MO) patients and correlated with markers of inflammation and nitrooxidative stress. We aimed to evaluate the changes of serum chemerin six months after laparoscopic sleeve gastrectomy (SG) and to asses if these changes are...
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doaj-d5ccb7affc124daca48bab0e17447fcd2020-11-24T23:05:09ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942018-01-01201810.1155/2018/15832121583212Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve GastrectomyAdriana Florinela Cӑtoi0Alina Elena Pârvu1Aurel Mironiuc2Ştefan Chiorescu3Alexandra Crӑciun4Ioana Delia Pop5Cornel Cӑtoi6Pathophysiology Department, Faculty of Medicine, “Iuliu Hațieganu”, University of Medicine and Pharmacy, Cluj-Napoca, RomaniaPathophysiology Department, Faculty of Medicine, “Iuliu Hațieganu”, University of Medicine and Pharmacy, Cluj-Napoca, RomaniaSecond Surgical Clinic, Faculty of Medicine, “Iuliu Hațieganu”, University of Medicine and Pharmacy, Cluj-Napoca, RomaniaSecond Surgical Clinic, Faculty of Medicine, “Iuliu Hațieganu”, University of Medicine and Pharmacy, Cluj-Napoca, RomaniaBiochemistry Department, Faculty of Medicine, “Iuliu Hațieganu”, University of Medicine and Pharmacy, Cluj-Napoca, RomaniaExact Sciences Department, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, RomaniaPathology Department, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, RomaniaBackground. Chemerin is a chemokine known to be increased in morbidly obese (MO) patients and correlated with markers of inflammation and nitrooxidative stress. We aimed to evaluate the changes of serum chemerin six months after laparoscopic sleeve gastrectomy (SG) and to asses if these changes are accompanied by variations of inflammatory and nitrooxidative stress markers. Material and Methods. We investigated the levels of chemerin, high-sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), and oxidative stress index (OSI) in a group of 24 MO patients submitted to SG before and six months after surgery. The MO group was compared with 20 controls. Results. hsCRP (p<0.001), NOx (p<0.001), TOS (p<0.001), TAR (p=0.007), and OSI (p=0.001) were significantly different between the two groups. Six months after surgery, we noticed significant changes (42.28% decrease) of hsCRP (p=0.044) and OSI (p=0.041) (31.81% decrease), while no significant changes were observed for chemerin (p=0.605), TNF-α (p=0.287), NOx (p=0.137), TOS (p=0.158), and TAR (p=0.563). Conclusions. Our study showed no significant changes of chemerin, and except for hsCRP and OSI, no other inflammatory and nitrooxidative stress markers changed six months after surgery.http://dx.doi.org/10.1155/2018/1583212 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adriana Florinela Cӑtoi Alina Elena Pârvu Aurel Mironiuc Ştefan Chiorescu Alexandra Crӑciun Ioana Delia Pop Cornel Cӑtoi |
spellingShingle |
Adriana Florinela Cӑtoi Alina Elena Pârvu Aurel Mironiuc Ştefan Chiorescu Alexandra Crӑciun Ioana Delia Pop Cornel Cӑtoi Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy Oxidative Medicine and Cellular Longevity |
author_facet |
Adriana Florinela Cӑtoi Alina Elena Pârvu Aurel Mironiuc Ştefan Chiorescu Alexandra Crӑciun Ioana Delia Pop Cornel Cӑtoi |
author_sort |
Adriana Florinela Cӑtoi |
title |
Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy |
title_short |
Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy |
title_full |
Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy |
title_fullStr |
Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy |
title_full_unstemmed |
Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy |
title_sort |
chemerin, inflammatory, and nitrooxidative stress marker changes six months after sleeve gastrectomy |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2018-01-01 |
description |
Background. Chemerin is a chemokine known to be increased in morbidly obese (MO) patients and correlated with markers of inflammation and nitrooxidative stress. We aimed to evaluate the changes of serum chemerin six months after laparoscopic sleeve gastrectomy (SG) and to asses if these changes are accompanied by variations of inflammatory and nitrooxidative stress markers. Material and Methods. We investigated the levels of chemerin, high-sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), and oxidative stress index (OSI) in a group of 24 MO patients submitted to SG before and six months after surgery. The MO group was compared with 20 controls. Results. hsCRP (p<0.001), NOx (p<0.001), TOS (p<0.001), TAR (p=0.007), and OSI (p=0.001) were significantly different between the two groups. Six months after surgery, we noticed significant changes (42.28% decrease) of hsCRP (p=0.044) and OSI (p=0.041) (31.81% decrease), while no significant changes were observed for chemerin (p=0.605), TNF-α (p=0.287), NOx (p=0.137), TOS (p=0.158), and TAR (p=0.563). Conclusions. Our study showed no significant changes of chemerin, and except for hsCRP and OSI, no other inflammatory and nitrooxidative stress markers changed six months after surgery. |
url |
http://dx.doi.org/10.1155/2018/1583212 |
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