Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12
In order to identify new markers around the glaucoma locus GLC1B as a tool to refine its critical region at 2p11.2-2q11.2, we searched the critical region sequence obtained from the UCSC database for tetranucleotide (GATA)n and (GTCT)n repeats of at least 10 units in length. Three out of four potent...
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2009-01-01
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doaj-d5d6d129e2cd41eb901dc3b5cf23dd152020-11-25T00:46:04ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852009-01-01324720722Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12Carlos Murga-ZamalloaMaria Luisa Guevara-FujitaAlejandro Estrada-CuzcanoRicardo FujitaIn order to identify new markers around the glaucoma locus GLC1B as a tool to refine its critical region at 2p11.2-2q11.2, we searched the critical region sequence obtained from the UCSC database for tetranucleotide (GATA)n and (GTCT)n repeats of at least 10 units in length. Three out of four potential microsatellite loci were found to be polymorphic, heterozygosity ranging from 64.56% to 79.59%. The identified markers are useful not only for GLC1B locus but also for the study of other disease loci at 2p11.2-2q11.2, a region with scarcity of microsatellite markers.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000400009GLC1Bmicrosatellite polymorphic markerstetranucleotide tandem repeatgene mappingglaucoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlos Murga-Zamalloa Maria Luisa Guevara-Fujita Alejandro Estrada-Cuzcano Ricardo Fujita |
spellingShingle |
Carlos Murga-Zamalloa Maria Luisa Guevara-Fujita Alejandro Estrada-Cuzcano Ricardo Fujita Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12 Genetics and Molecular Biology GLC1B microsatellite polymorphic markers tetranucleotide tandem repeat gene mapping glaucoma |
author_facet |
Carlos Murga-Zamalloa Maria Luisa Guevara-Fujita Alejandro Estrada-Cuzcano Ricardo Fujita |
author_sort |
Carlos Murga-Zamalloa |
title |
Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12 |
title_short |
Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12 |
title_full |
Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12 |
title_fullStr |
Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12 |
title_full_unstemmed |
Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12 |
title_sort |
three novel polymorphic microsatellite markers for the glaucoma locus glc1b by datamining tetranucleotide repeats on chromosome 2p12-q12 |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1415-4757 1678-4685 |
publishDate |
2009-01-01 |
description |
In order to identify new markers around the glaucoma locus GLC1B as a tool to refine its critical region at 2p11.2-2q11.2, we searched the critical region sequence obtained from the UCSC database for tetranucleotide (GATA)n and (GTCT)n repeats of at least 10 units in length. Three out of four potential microsatellite loci were found to be polymorphic, heterozygosity ranging from 64.56% to 79.59%. The identified markers are useful not only for GLC1B locus but also for the study of other disease loci at 2p11.2-2q11.2, a region with scarcity of microsatellite markers. |
topic |
GLC1B microsatellite polymorphic markers tetranucleotide tandem repeat gene mapping glaucoma |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000400009 |
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