Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor

TSH-secreting pituitary neuroendocrine tumor (PitNET) is one of the causes of central hyperthyroidism. The incidence of TSH PitNET is far lower than that of other PitNETs. The clinical manifestations of TSH PitNETs mainly include thyrotoxicosis or thyroid goiter, secretion disorders of other anterio...

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Main Authors:	Peiqiong Luo, Lin Zhang, Lidan Yang, Zhenmei An, Huiwen Tan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Endocrinology
Subjects:	thyroid-stimulating hormone-secreting pituitary adenoma hyperthyroidism pituitary adenoma pathogenesis diagnosis treatment
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2020.580264/full

id	doaj-d5da8f87ff044936ab15d39e66b23ba8
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spelling	doaj-d5da8f87ff044936ab15d39e66b23ba82020-12-08T08:40:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-11-011110.3389/fendo.2020.580264580264Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine TumorPeiqiong Luo0Lin Zhang1Lidan Yang2Zhenmei An3Huiwen Tan4Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of General Practice, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, ChinaTSH-secreting pituitary neuroendocrine tumor (PitNET) is one of the causes of central hyperthyroidism. The incidence of TSH PitNET is far lower than that of other PitNETs. The clinical manifestations of TSH PitNETs mainly include thyrotoxicosis or thyroid goiter, secretion disorders of other anterior pituitary hormones, and mass effect on the pituitary gland and its surrounding tissues. The application of high-sensitivity TSH detection methods contributes to the early diagnosis and timely treatment of TSH PitNETs. Improvements in magnetic resonance imaging (MRI) have advanced the noninvasive visualization of smaller PitNETs. Treatments for TSH PitNETs include surgery, drugs, and radiotherapy. This review focuses on the progress in pathogenesis, diagnosis, and treatment of TSH PitNETs to provide more information for the clinician.https://www.frontiersin.org/articles/10.3389/fendo.2020.580264/fullthyroid-stimulating hormone-secreting pituitary adenomahyperthyroidismpituitary adenomapathogenesisdiagnosistreatment
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Peiqiong Luo Lin Zhang Lidan Yang Zhenmei An Huiwen Tan
spellingShingle	Peiqiong Luo Lin Zhang Lidan Yang Zhenmei An Huiwen Tan Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor Frontiers in Endocrinology thyroid-stimulating hormone-secreting pituitary adenoma hyperthyroidism pituitary adenoma pathogenesis diagnosis treatment
author_facet	Peiqiong Luo Lin Zhang Lidan Yang Zhenmei An Huiwen Tan
author_sort	Peiqiong Luo
title	Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor
title_short	Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor
title_full	Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor
title_fullStr	Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor
title_full_unstemmed	Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor
title_sort	progress in the pathogenesis, diagnosis, and treatment of tsh-secreting pituitary neuroendocrine tumor
publisher	Frontiers Media S.A.
series	Frontiers in Endocrinology
issn	1664-2392
publishDate	2020-11-01
description	TSH-secreting pituitary neuroendocrine tumor (PitNET) is one of the causes of central hyperthyroidism. The incidence of TSH PitNET is far lower than that of other PitNETs. The clinical manifestations of TSH PitNETs mainly include thyrotoxicosis or thyroid goiter, secretion disorders of other anterior pituitary hormones, and mass effect on the pituitary gland and its surrounding tissues. The application of high-sensitivity TSH detection methods contributes to the early diagnosis and timely treatment of TSH PitNETs. Improvements in magnetic resonance imaging (MRI) have advanced the noninvasive visualization of smaller PitNETs. Treatments for TSH PitNETs include surgery, drugs, and radiotherapy. This review focuses on the progress in pathogenesis, diagnosis, and treatment of TSH PitNETs to provide more information for the clinician.
topic	thyroid-stimulating hormone-secreting pituitary adenoma hyperthyroidism pituitary adenoma pathogenesis diagnosis treatment
url	https://www.frontiersin.org/articles/10.3389/fendo.2020.580264/full
work_keys_str_mv	AT peiqiongluo progressinthepathogenesisdiagnosisandtreatmentoftshsecretingpituitaryneuroendocrinetumor AT linzhang progressinthepathogenesisdiagnosisandtreatmentoftshsecretingpituitaryneuroendocrinetumor AT lidanyang progressinthepathogenesisdiagnosisandtreatmentoftshsecretingpituitaryneuroendocrinetumor AT zhenmeian progressinthepathogenesisdiagnosisandtreatmentoftshsecretingpituitaryneuroendocrinetumor AT huiwentan progressinthepathogenesisdiagnosisandtreatmentoftshsecretingpituitaryneuroendocrinetumor
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Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor

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