Cytokine-Induced Memory-Like NK Cells with High Reactivity against Acute Leukemia Blasts and Solid Tumor Cells Suitable for Adoptive Immunotherapy Approaches

Cytokine-Induced Memory-Like NK Cells with High Reactivity against Acute Leukemia Blasts and Solid Tumor Cells Suitable for Adoptive Immunotherapy Approaches

The limited efficacy of Natural Killer (NK) cell-based immunotherapy results in part from the suboptimal expansion and persistence of the infused cells. Recent reports suggest that the generation of NK cells with memory-like properties upon in vitro activation with defined cytokines might be an effe...

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Bibliographic Details
Main Authors: Matteo Tanzi, Michela Consonni, Michela Falco, Federica Ferulli, Enrica Montini, Annamaria Pasi, Rosalia Cacciatore, Silvia Brugnatelli, Paolo Pedrazzoli, Marco Zecca, Stella Boghen, Paolo Dellabona, Giulia Casorati, Daniela Montagna
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
NK-based immunotherapy
haploidentical hematopoietic stem cell transplantation
pediatric leukemia
solid tumors
NK-alloreactivity
Online Access:https://www.mdpi.com/2072-6694/13/7/1577

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