Chemistry and Structure-Activity Relationship of the Styrylquinoline-Type HIV Integrase Inhibitors

Chemistry and Structure-Activity Relationship of the Styrylquinoline-Type HIV Integrase Inhibitors

In spite of significant progress in anti-HIV-1 therapy, current antiviral chemo-therapy still suffers from deleterious side effects and emerging drug resistance. Therefore, the development of novel antiviral drugs remains a crucial issue for the fight against AIDS. HIV-1 integrase is a key enzyme in...

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Bibliographic Details
Main Authors: Didier Desmaële, Jean-François Mouscadet
Format: Article
Language:English
Published: MDPI AG 2010-04-01
Series:Molecules
Subjects:
AIDS
HIV-1
integrase
inhibitor
styrylquinoline
Online Access:http://www.mdpi.com/1420-3049/15/5/3048/

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