Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In Vitro
The root of Paeonia lactiflora and the stem of Sinomenium acutum are two herbs widely used in Chinese herbal medicine for the treatment of inflammatory and arthritic diseases. Studies on the interaction of the active constituents of these herbs, i.e., paeoniflorin and sinomenine, in pharmacokinetic...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2005-01-01
|
Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319320778 |
id |
doaj-d5f400bbf0004a9bb370da4d4a9de9c8 |
---|---|
record_format |
Article |
spelling |
doaj-d5f400bbf0004a9bb370da4d4a9de9c82020-11-24T21:49:56ZengElsevierJournal of Pharmacological Sciences1347-86132005-01-01994381391Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In VitroZhong Qiu Liu0Zhi Hong Jiang1Kelvin Chan2Hua Zhou3Yuen Fan Wong4Zhao Xiang Bian5Hong Xi Xu6Liang Liu7School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, ChinaHong Kong Jockey Club Institute of Chinese Medicine Limited, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China; Corresponding author. FAX: +852 34112461 E-mail: liuliang@hkbu.edu.hkThe root of Paeonia lactiflora and the stem of Sinomenium acutum are two herbs widely used in Chinese herbal medicine for the treatment of inflammatory and arthritic diseases. Studies on the interaction of the active constituents of these herbs, i.e., paeoniflorin and sinomenine, in pharmacokinetic parameters, tissues distribution, and protein binding ability could provide empirical data to support their clinical application. Following oral administration to rats, the pharmacokinetic alterations were compared. The results showed that the pharmacokinetic parameters (Cmax, Tmax, AUC, MRT, CL, and Vd) of paeoniflorin were markedly enhanced when co-administrated with sinomenine. At 45 min after oral administration, the concentrations of paeoniflorin in the main internal organs were significantly increased when co-administrated with sinomenine. These phenomena were not ascribable to the alteration of the protein binding ability of paeoniflorin by sinomenine because obvious interactions of paeoniflorin and sinomenine in protein binding abilities in vitro to rat and rabbit plasma, human albumin, and α-1-acid-glycoprotein were not observed. However, with respect to the in vivo influence of paeoniflorin on sinomenine, the results showed that co-administration of paeoniflorin did not affect the pharmacokinetic parameters and tissue distribution of sinomenine. Keywords:: paeoniflorin, sinomenine, pharmacokinetics, bioavailability, tissue distributionhttp://www.sciencedirect.com/science/article/pii/S1347861319320778 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhong Qiu Liu Zhi Hong Jiang Kelvin Chan Hua Zhou Yuen Fan Wong Zhao Xiang Bian Hong Xi Xu Liang Liu |
spellingShingle |
Zhong Qiu Liu Zhi Hong Jiang Kelvin Chan Hua Zhou Yuen Fan Wong Zhao Xiang Bian Hong Xi Xu Liang Liu Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In Vitro Journal of Pharmacological Sciences |
author_facet |
Zhong Qiu Liu Zhi Hong Jiang Kelvin Chan Hua Zhou Yuen Fan Wong Zhao Xiang Bian Hong Xi Xu Liang Liu |
author_sort |
Zhong Qiu Liu |
title |
Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In Vitro |
title_short |
Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In Vitro |
title_full |
Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In Vitro |
title_fullStr |
Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In Vitro |
title_full_unstemmed |
Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In Vitro |
title_sort |
pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro |
publisher |
Elsevier |
series |
Journal of Pharmacological Sciences |
issn |
1347-8613 |
publishDate |
2005-01-01 |
description |
The root of Paeonia lactiflora and the stem of Sinomenium acutum are two herbs widely used in Chinese herbal medicine for the treatment of inflammatory and arthritic diseases. Studies on the interaction of the active constituents of these herbs, i.e., paeoniflorin and sinomenine, in pharmacokinetic parameters, tissues distribution, and protein binding ability could provide empirical data to support their clinical application. Following oral administration to rats, the pharmacokinetic alterations were compared. The results showed that the pharmacokinetic parameters (Cmax, Tmax, AUC, MRT, CL, and Vd) of paeoniflorin were markedly enhanced when co-administrated with sinomenine. At 45 min after oral administration, the concentrations of paeoniflorin in the main internal organs were significantly increased when co-administrated with sinomenine. These phenomena were not ascribable to the alteration of the protein binding ability of paeoniflorin by sinomenine because obvious interactions of paeoniflorin and sinomenine in protein binding abilities in vitro to rat and rabbit plasma, human albumin, and α-1-acid-glycoprotein were not observed. However, with respect to the in vivo influence of paeoniflorin on sinomenine, the results showed that co-administration of paeoniflorin did not affect the pharmacokinetic parameters and tissue distribution of sinomenine. Keywords:: paeoniflorin, sinomenine, pharmacokinetics, bioavailability, tissue distribution |
url |
http://www.sciencedirect.com/science/article/pii/S1347861319320778 |
work_keys_str_mv |
AT zhongqiuliu pharmacokineticinteractionofpaeoniflorinandsinomeninepharmacokineticparametersandtissuedistributioncharacteristicsinratsandproteinbindingabilityinvitro AT zhihongjiang pharmacokineticinteractionofpaeoniflorinandsinomeninepharmacokineticparametersandtissuedistributioncharacteristicsinratsandproteinbindingabilityinvitro AT kelvinchan pharmacokineticinteractionofpaeoniflorinandsinomeninepharmacokineticparametersandtissuedistributioncharacteristicsinratsandproteinbindingabilityinvitro AT huazhou pharmacokineticinteractionofpaeoniflorinandsinomeninepharmacokineticparametersandtissuedistributioncharacteristicsinratsandproteinbindingabilityinvitro AT yuenfanwong pharmacokineticinteractionofpaeoniflorinandsinomeninepharmacokineticparametersandtissuedistributioncharacteristicsinratsandproteinbindingabilityinvitro AT zhaoxiangbian pharmacokineticinteractionofpaeoniflorinandsinomeninepharmacokineticparametersandtissuedistributioncharacteristicsinratsandproteinbindingabilityinvitro AT hongxixu pharmacokineticinteractionofpaeoniflorinandsinomeninepharmacokineticparametersandtissuedistributioncharacteristicsinratsandproteinbindingabilityinvitro AT liangliu pharmacokineticinteractionofpaeoniflorinandsinomeninepharmacokineticparametersandtissuedistributioncharacteristicsinratsandproteinbindingabilityinvitro |
_version_ |
1725886355311951872 |