VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study
François Niforos,1 Patricia Ogilvie,2 Maurizio Cavallini,3 Christophe Leys,4 Jonquille Chantrey,5 Marva Safa,6 Steve Abrams,7 René Hopfinger,7 Ann Marx7 1Centre Chirurgical Niforos, Lyon, France; 2SkinConcept, Munich, Germany; 3Unit of Plastic Surgery, CDI Hospital, Milan, Ital...
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doaj-d5f8a3d30a18459d862d156c24e3ec012020-11-25T01:17:08ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152019-10-01Volume 1279179849309VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective StudyNiforos FOgilvie PCavallini MLeys CChantrey JSafa MAbrams SHopfinger RMarx AFrançois Niforos,1 Patricia Ogilvie,2 Maurizio Cavallini,3 Christophe Leys,4 Jonquille Chantrey,5 Marva Safa,6 Steve Abrams,7 René Hopfinger,7 Ann Marx7 1Centre Chirurgical Niforos, Lyon, France; 2SkinConcept, Munich, Germany; 3Unit of Plastic Surgery, CDI Hospital, Milan, Italy; 4Medical Skincare, Sint-Truiden, Belgium; 5ØNE aesthetic studiø, Cheshire, UK; 6La Jouvence, Neuchâtel, Switzerland; 7Clinical Development, Allergan Plc, Irvine, CA, USACorrespondence: François NiforosCentre Chirurgical Niforos, 55 Boulevard Des Belges, Lyon 69006, FranceTel +33 4 78 93 95 55Fax +33 4 72 82 92 49Email fniforos@niforos.frObjective: Evaluate safety and effectiveness of VYC-12 (Juvéderm Volite; an injectable crosslinked hyaluronic acid gel designed to improve skin quality attributes such as surface smoothness and hydration) for facial intradermal injection.Materials and methods: In a prospective, single-arm study, subjects with moderate/severe cheek skin roughness per Allergan Skin Roughness Scale (ASRS) received VYC-12 in the cheeks and forehead, and/or neck, with touch-up treatment to correct asymmetry 30 days later and optional repeat treatment 9 months after last treatment. The primary effectiveness measure was ASRS responder rate (percentage of cheeks with ≥1-point improvement from baseline) at month 1. Skin hydration was instrument-assessed.Results: Of 131 subjects treated, 31 (23.7%) received touch-up treatment. ASRS responder rate was 96.2% at month 1, 76.3% at month 4, 34.9% at month 6, and 87.1% after repeat treatment. Responder rate in cheeks with severe baseline roughness was 93.8%, 83.1%, and 52.3% at months 1, 4, and 6, respectively. Skin hydration improved significantly (P<0.01) from baseline at all timepoints through month 9. Injection site responses were as expected. All treatment-related adverse events were mild/moderate.Conclusion: VYC-12 safely and effectively improved skin smoothness up to 6 months and hydration lasting 9 months.Keywords: hyaluronic acid, injectable dermal filler, Juvéderm Volite, skin aginghttps://www.dovepress.com/vyc-12-injectable-gel-is-safe-and-effective-for-improvement-of-facial--peer-reviewed-article-CCIDhyaluronic acidinjectable dermal fillerJuvéderm Voliteskin aging |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Niforos F Ogilvie P Cavallini M Leys C Chantrey J Safa M Abrams S Hopfinger R Marx A |
spellingShingle |
Niforos F Ogilvie P Cavallini M Leys C Chantrey J Safa M Abrams S Hopfinger R Marx A VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study Clinical, Cosmetic and Investigational Dermatology hyaluronic acid injectable dermal filler Juvéderm Volite skin aging |
author_facet |
Niforos F Ogilvie P Cavallini M Leys C Chantrey J Safa M Abrams S Hopfinger R Marx A |
author_sort |
Niforos F |
title |
VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study |
title_short |
VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study |
title_full |
VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study |
title_fullStr |
VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study |
title_full_unstemmed |
VYC-12 Injectable Gel Is Safe And Effective For Improvement Of Facial Skin Topography: A Prospective Study |
title_sort |
vyc-12 injectable gel is safe and effective for improvement of facial skin topography: a prospective study |
publisher |
Dove Medical Press |
series |
Clinical, Cosmetic and Investigational Dermatology |
issn |
1178-7015 |
publishDate |
2019-10-01 |
description |
François Niforos,1 Patricia Ogilvie,2 Maurizio Cavallini,3 Christophe Leys,4 Jonquille Chantrey,5 Marva Safa,6 Steve Abrams,7 René Hopfinger,7 Ann Marx7 1Centre Chirurgical Niforos, Lyon, France; 2SkinConcept, Munich, Germany; 3Unit of Plastic Surgery, CDI Hospital, Milan, Italy; 4Medical Skincare, Sint-Truiden, Belgium; 5ØNE aesthetic studiø, Cheshire, UK; 6La Jouvence, Neuchâtel, Switzerland; 7Clinical Development, Allergan Plc, Irvine, CA, USACorrespondence: François NiforosCentre Chirurgical Niforos, 55 Boulevard Des Belges, Lyon 69006, FranceTel +33 4 78 93 95 55Fax +33 4 72 82 92 49Email fniforos@niforos.frObjective: Evaluate safety and effectiveness of VYC-12 (Juvéderm Volite; an injectable crosslinked hyaluronic acid gel designed to improve skin quality attributes such as surface smoothness and hydration) for facial intradermal injection.Materials and methods: In a prospective, single-arm study, subjects with moderate/severe cheek skin roughness per Allergan Skin Roughness Scale (ASRS) received VYC-12 in the cheeks and forehead, and/or neck, with touch-up treatment to correct asymmetry 30 days later and optional repeat treatment 9 months after last treatment. The primary effectiveness measure was ASRS responder rate (percentage of cheeks with ≥1-point improvement from baseline) at month 1. Skin hydration was instrument-assessed.Results: Of 131 subjects treated, 31 (23.7%) received touch-up treatment. ASRS responder rate was 96.2% at month 1, 76.3% at month 4, 34.9% at month 6, and 87.1% after repeat treatment. Responder rate in cheeks with severe baseline roughness was 93.8%, 83.1%, and 52.3% at months 1, 4, and 6, respectively. Skin hydration improved significantly (P<0.01) from baseline at all timepoints through month 9. Injection site responses were as expected. All treatment-related adverse events were mild/moderate.Conclusion: VYC-12 safely and effectively improved skin smoothness up to 6 months and hydration lasting 9 months.Keywords: hyaluronic acid, injectable dermal filler, Juvéderm Volite, skin aging |
topic |
hyaluronic acid injectable dermal filler Juvéderm Volite skin aging |
url |
https://www.dovepress.com/vyc-12-injectable-gel-is-safe-and-effective-for-improvement-of-facial--peer-reviewed-article-CCID |
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