TrkB agonistic antibodies superior to BDNF: Utility in treating motoneuron degeneration

TrkB agonistic antibodies superior to BDNF: Utility in treating motoneuron degeneration

While Brain-derived Neurotrophic Factor (BDNF) has long been implicated in treating neurological diseases, recombinant BDNF protein has failed in multiple clinical trials. In addition to its unstable and adhesive nature, BDNF can activate p75NTR, a receptor mediating cellular functions opposite to t...

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Bibliographic Details
Main Authors: Wei Guo, Keliang Pang, Yanbo Chen, Shudan Wang, Heng Li, Yihua Xu, Fang Han, Hongyang Yao, Hang Liu, Vanessa Lopes-Rodrigues, Dang Sun, Jingyu Shao, Jianying Shen, Yang Dou, Wen Zhang, He You, Wutian Wu, Bai Lu
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Neurobiology of Disease
Subjects:
Receptor tyrosine kinase
Neurotrophin
BDNF
TrkB signaling
Agonistic antibody
Monoclonal antibody
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611930258X

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