Lipoprotein(a) and fibrinogen as predictors of complications in patients with acute coronary syndrome

• Main Authors: Pedro A. Carvajal Sánchez, Ana M. Correa Morales, Luis M. Reyes Hernández, Rosa E. Díaz Benítez, Enma M. González Rivera, Misleidis García Márquez
• Format: Article
• Language: English
• Published: Cardiocentro Ernesto Che Guevara 2016-01-01
• Series: CorSalud
• Online Access: http://www.revcorsalud.sld.cu/index.php/cors/article/view/75

Introduction: Cardiovascular diseases are the cause of the largest number of annual deaths in the developped world, so they are considered a scourge on mankind; these include ischemic heart disease.<br />Objectives: To determine the value of lipoprotein(a), fibrinogen and fibrinogen-lipoprotein(a) index in predicting short-term complications in patients with acute coronary syndrome.<br />Method: A cross-sectional descriptive study was conducted in 115 patients admitted with acute coronary syndrome to the Dr. Celestino Hernández Robau Hospital in Santa Clara, from November 2012 to October 2013.<br />Results: The study included 43 female and 72 male patients. The most frequent risk factors included hypertension (70.43%), dyslipidemia (50.43%) and a family history of coronary artery disease (47.83%). Complications occurred in 39 patients (33.9%). Cut-off points were established at 4.50 g/L for fibrinogen, 341 mg/L for lipoprotein(a) and 1.50 for fibrinogen-lipoprotein(a) index, which showed a sensitivity of 89%, specificity of 94% and a predictive ability given by an odds ratio of 122. Therefore it was classified as having a very good predictive value.<br />Conclusions: The fibrinogen-lipoprotein(a) index showed an excellent predictive value for short-term complications in patients with acute coronary syndrome.