Regeneration and activation of liver progenitor cells in liver cirrhosis
Cirrhosis is characterized as the progress of regenerative nodules surrounded by fibrous bands in response to chronic hepatic injury and causes portal hypertension and end-stage hepatic disease. Following liver injury, liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes...
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2021-09-01
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doaj-d60dc5e4736d494f8ae6553902e8c9672021-07-15T04:27:54ZengElsevierGenes and Diseases2352-30422021-09-0185623628Regeneration and activation of liver progenitor cells in liver cirrhosisYanze Yin0Defu Kong1Kang He2Qiang Xia3Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, PR ChinaDepartment of Hepatology & Gastroenterology, University Medical Center Groningen, Groningen, 9713, the NetherlandsDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, PR China; Corresponding author.Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, PR China; Corresponding author.Cirrhosis is characterized as the progress of regenerative nodules surrounded by fibrous bands in response to chronic hepatic injury and causes portal hypertension and end-stage hepatic disease. Following liver injury, liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes in order to awaken liver regeneration and reach homeostasis. Recent research has uncovered some new sources of LPCs. Here, we update the mechanisms of LPCs-mediated liver regeneration in cirrhosis by introducing the origin of LPCs and LPCs’ niche with a discussion of the influence of LPC-related cells. This article analyzes the mechanism of regeneration and activation of LPCs in cirrhosis in recent years aiming to provide help for clinical application.http://www.sciencedirect.com/science/article/pii/S2352304220300994ActivationCytokinesExtracellular matrixHepatic stellate cellsLiver cirrhosisLiver progenitor cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanze Yin Defu Kong Kang He Qiang Xia |
spellingShingle |
Yanze Yin Defu Kong Kang He Qiang Xia Regeneration and activation of liver progenitor cells in liver cirrhosis Genes and Diseases Activation Cytokines Extracellular matrix Hepatic stellate cells Liver cirrhosis Liver progenitor cells |
author_facet |
Yanze Yin Defu Kong Kang He Qiang Xia |
author_sort |
Yanze Yin |
title |
Regeneration and activation of liver progenitor cells in liver cirrhosis |
title_short |
Regeneration and activation of liver progenitor cells in liver cirrhosis |
title_full |
Regeneration and activation of liver progenitor cells in liver cirrhosis |
title_fullStr |
Regeneration and activation of liver progenitor cells in liver cirrhosis |
title_full_unstemmed |
Regeneration and activation of liver progenitor cells in liver cirrhosis |
title_sort |
regeneration and activation of liver progenitor cells in liver cirrhosis |
publisher |
Elsevier |
series |
Genes and Diseases |
issn |
2352-3042 |
publishDate |
2021-09-01 |
description |
Cirrhosis is characterized as the progress of regenerative nodules surrounded by fibrous bands in response to chronic hepatic injury and causes portal hypertension and end-stage hepatic disease. Following liver injury, liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes in order to awaken liver regeneration and reach homeostasis. Recent research has uncovered some new sources of LPCs. Here, we update the mechanisms of LPCs-mediated liver regeneration in cirrhosis by introducing the origin of LPCs and LPCs’ niche with a discussion of the influence of LPC-related cells. This article analyzes the mechanism of regeneration and activation of LPCs in cirrhosis in recent years aiming to provide help for clinical application. |
topic |
Activation Cytokines Extracellular matrix Hepatic stellate cells Liver cirrhosis Liver progenitor cells |
url |
http://www.sciencedirect.com/science/article/pii/S2352304220300994 |
work_keys_str_mv |
AT yanzeyin regenerationandactivationofliverprogenitorcellsinlivercirrhosis AT defukong regenerationandactivationofliverprogenitorcellsinlivercirrhosis AT kanghe regenerationandactivationofliverprogenitorcellsinlivercirrhosis AT qiangxia regenerationandactivationofliverprogenitorcellsinlivercirrhosis |
_version_ |
1721301931191697408 |