Expression of serum Chemerin in the diabetic retinopathy patients and its clinical implication

• Main Authors: Jing Yang, Peng Nie, Chun-Jiu Hang
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2015-10-01
• Series: Guoji Yanke Zazhi
• Subjects: diabetic retinopathy; Chemerin; diabetes mellitus
• Online Access: http://ies.ijo.cn/cn_publish/2015/10/201510010.pdf
• ISSN: 1672-5123; 1672-5123

AIM: To investigate the level changes of serum Chemerin in patients with diabetic retinopathy(DR)and explore its role in the development of DR. <p>METHODS: A total of 90 diabetes patients from January 2012 to December 2013 were enrolled, including non-diabetic retinopathy(NDR,<i>n</i>=30), simple diabetic retinopathy(SDR, <i>n</i>=30), proliferative diabetic retinopathy(PDR, <i>n</i>=30). Thirty healthy persons were included as normal control(NC). Chemerin level, tumor necrosis factor-α(TNF-α), adiponectin were assessed by enzyme-linked immunosorbent assay.Clinical characters including BMI, underlying diseases, blood lipids <i>ect. </i>were collected. <p>RESULTS: The serum levels of Chemerin in NC, NDR, SDR, and PDR group were 12.35±3.56, 26.50±5.34, 34.67±7.72, 40.97±8.97μg/L respectively. The serum levels of Chemerin in SDR and PDR group were significantly higher than those in NC and NDR group(<i>P</i><0.01). Serum levels of Chemerin positively correlated with TNF-α(<i>r</i>=0.8746, <i>P</i><0.01)and negatively correlated with adiponectin(<i>r</i>=-0.7418,<i>P</i><0.01). The results of Logistic regression analysis showed that Chemerin was an independent risk factor for DR(<i>OR</i>=8.458, 95%<i>CI</i>: 1.611～44.410, <i>P</i>=0.012).<p>CONCLUSION: The results show that serum Chemerin level is significantly elevated in DR patients, and Chemerin may be involved in the development of DR.