Risk Factors of Invasive Pulmonary Fungal Infections in Patients with Hepatitis B Virus Related Acute-on-Chronic Liver Failure

• Main Authors: Xinchun He, Shigang Tang, Liang Chen, Yuqing Feng, Baining Zhu, Caixia Yang
• Format: Article
• Language: English
• Published: Hindawi Limited 2021-01-01
• Series: Journal of Nanomaterials
• Online Access: http://dx.doi.org/10.1155/2021/9260259

To analyze the risk factors of invasive pulmonary fungal infections in patients with HBV-ACL, the clinical data and risk factors of 60 patients with HBV-ACLF complicated IPFI were analyzed retrospectively including clinical parameters, broad-spectrum antibiotics usage, neutropenia, invasive medical manipulations, serum total bilirubin, international normalized ratio (INR), and MELD scores were compared with non-IPFI. Risk factors were analyzed using mathematical tools. Candida species and Aspergillus were detected as the most prominent fungal strains (61.11% and 33.33%, respectively). The risk factors included prolong broad-spectrum antibiotic usage OR=4.362,P=0.008, neutropenia OR=3.288,P=0.007, invasive procedures OR=3.263,P=0.010, serum total bilirubin OR=1.006,P=0.011, INR OR=2.101,P=0.007, and MELD scores OR=1.074,P=0.008. Candida is the main IPFI strains in patients with HBV-ACLF. Broad-spectrum antibiotics usage, neutropenia, invasive manipulations, and the severity of ACLF might be risk factors for IPFI in patients with HBV-ACLF.