Rebound inflammation after an intravitreal injection in Vogt–Koyanagi–Harada syndrome

• Main Authors: Richa Ranjan, Manisha Agarwal
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Indian Journal of Ophthalmology
• Subjects: Choroidal neovascular membrane; exudative retinal detachment; intravitreal injection; Vogt–Koyanagi–Harada syndrome
• Online Access: http://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=6;spage=863;epage=865;aulast=Ranjan

A 43-year-old male with chronic Vogt–Koyanagi–Harada syndrome (VKH) presented with subfoveal choroidal neovascular membrane (CNVM) in the right eye with no evidence of active inflammation. He underwent intravitreal bevacizumab and dexamethasone injections. Postinjection he developed fresh keratic precipitates and exudative retinal detachment (RD). He received two more bevacizumab injections with oral corticosteroids and immunosuppressants causing resolution of exudative RD with scarred CNVM. We report this case to highlight that intravitreal injection may act as a trigger for rebound inflammation in VKH patients and may require anti-inflammatory drugs to be started even in the absence of an active inflammation.