Relationship between total antioxidant capacity and the severity of coronary artery disease

• Main Authors: Ramazan Yiğitoğlu, Bora Demirçelik, Metin Canbal, Kadir Serkan Yalçın, Necmettin Çolak, Yunus Nazlı, Yusuf Selcoki, Murat Aydın, Beyhan Eryonucu
• Format: Article
• Language: English
• Published: Modestum Publishing LTD 2012-03-01
• Series: Journal of Clinical and Experimental Investigations
• Subjects: coronary artery disease; total antioxidant capacity; oxidative stress
• Online Access: http://www.jceionline.org/upload/sayi/8/JCEI-00423.pdf
• ISSN: 1309-8578; 1309-6621

Objectives: It was known that oxidative/antioxidative balanceshifted to oxidative side in patients with coronaryartery disease. The aim of this study is to evaluate therelationship between coronary artery disease and totalantioxidant status, oxidative stress index.Materials and methods: The study group consisted of87 consecutive patients who were hospitalized for coronaryangiography. Plasma total oxidative status (TOS)and total antioxidative capacity (TAC) levels were measuredand oxidative stress index (OSI) was calculated.Results: The TAC values increased statistically significantin the four tertile compared with the first tertile (1.9± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS valuesdecreased non- significantly in the four tertile ( 5.2 ± 2.8vs 7.2 ± 5.4 μmol H2O2 Eq/l) as compared to the patientsin the first tertile. According to the number of diseasedvessels, plasma oxidative characteristics did not differ betweenthe three groups.Conclusions: Plasma TAC levels increased in subjectswith coronary atherosclerosis and severity of coronaryatherosclerosis is related with TAC. J Clin Exp Invest2012; 3(1): 22-28