Prevention of Recurrent Acute Otitis Media in Children Through the Use of <i>Lactobacillus salivarius</i> PS7, a Target-Specific Probiotic Strain
Acute otitis media (AOM) is one of the most common bacterial infections in children. Empiric antibiotherapy leads to increasing antimicrobial resistance rates among otopathogens and may impair the correct development of the microbiota in early life. In this context, probiotics seem to be an attracti...
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doaj-d622093cdb0d46e2ab49a7a2c4ff803c2020-11-25T00:02:24ZengMDPI AGNutrients2072-66432019-02-0111237610.3390/nu11020376nu11020376Prevention of Recurrent Acute Otitis Media in Children Through the Use of <i>Lactobacillus salivarius</i> PS7, a Target-Specific Probiotic StrainNivia Cárdenas0Virginia Martín1Rebeca Arroyo2Mario López3Marta Carrera4Carlos Badiola5Esther Jiménez6Juan M. Rodríguez7Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainCentro de Salud Bermeo, Tonpoi Kalea, s/n, 48370 Bermeo, Bizkaia, SpainCentro de Salud Silvano, Av. de Machupichu, 58, 28043 Madrid, SpainLaboratorios Casen Recordati S.L., Vía de las Dos Castillas, 33, 28224 Pozuelo de Alarcón, Madrid, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainAcute otitis media (AOM) is one of the most common bacterial infections in children. Empiric antibiotherapy leads to increasing antimicrobial resistance rates among otopathogens and may impair the correct development of the microbiota in early life. In this context, probiotics seem to be an attractive approach for preventing recurrent AOM (rAOM) through the restoration of the middle ear and nasopharyngeal microbiota. The aim of this study was the selection of a probiotic strain (<i>Lactobacillus salivarius</i> PS7), specifically tailored for its antagonism against otopathogens. Since <i>L. salivarius</i> PS7 was safe and displayed a strong antimicrobial activity against otopathogens, its efficacy in preventing rAOM was assessed in a trial involving 61 children suffering from rAOM. Children consumed daily ~1 × 10<sup>9</sup> CFU of <i>L. salivarius</i> PS7, and the number of AOM episodes were registered and compared with that observed in the previous 6 and 12 months. The microbiota of samples collected from the external auditory canal samples was quantitatively and qualitatively assessed. The number of AOM episodes during the intervention period decreased significantly (84%) when compared to that reported during the 6 months period before the probiotic intervention. In conclusion, <i>L. salivarius</i> PS7 is a promising strain for the prevention of rAOM in infants and children.https://www.mdpi.com/2072-6643/11/2/376<i>Lactobacillus salivarius</i>otitisprobioticbacteriocinprevention |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nivia Cárdenas Virginia Martín Rebeca Arroyo Mario López Marta Carrera Carlos Badiola Esther Jiménez Juan M. Rodríguez |
spellingShingle |
Nivia Cárdenas Virginia Martín Rebeca Arroyo Mario López Marta Carrera Carlos Badiola Esther Jiménez Juan M. Rodríguez Prevention of Recurrent Acute Otitis Media in Children Through the Use of <i>Lactobacillus salivarius</i> PS7, a Target-Specific Probiotic Strain Nutrients <i>Lactobacillus salivarius</i> otitis probiotic bacteriocin prevention |
author_facet |
Nivia Cárdenas Virginia Martín Rebeca Arroyo Mario López Marta Carrera Carlos Badiola Esther Jiménez Juan M. Rodríguez |
author_sort |
Nivia Cárdenas |
title |
Prevention of Recurrent Acute Otitis Media in Children Through the Use of <i>Lactobacillus salivarius</i> PS7, a Target-Specific Probiotic Strain |
title_short |
Prevention of Recurrent Acute Otitis Media in Children Through the Use of <i>Lactobacillus salivarius</i> PS7, a Target-Specific Probiotic Strain |
title_full |
Prevention of Recurrent Acute Otitis Media in Children Through the Use of <i>Lactobacillus salivarius</i> PS7, a Target-Specific Probiotic Strain |
title_fullStr |
Prevention of Recurrent Acute Otitis Media in Children Through the Use of <i>Lactobacillus salivarius</i> PS7, a Target-Specific Probiotic Strain |
title_full_unstemmed |
Prevention of Recurrent Acute Otitis Media in Children Through the Use of <i>Lactobacillus salivarius</i> PS7, a Target-Specific Probiotic Strain |
title_sort |
prevention of recurrent acute otitis media in children through the use of <i>lactobacillus salivarius</i> ps7, a target-specific probiotic strain |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-02-01 |
description |
Acute otitis media (AOM) is one of the most common bacterial infections in children. Empiric antibiotherapy leads to increasing antimicrobial resistance rates among otopathogens and may impair the correct development of the microbiota in early life. In this context, probiotics seem to be an attractive approach for preventing recurrent AOM (rAOM) through the restoration of the middle ear and nasopharyngeal microbiota. The aim of this study was the selection of a probiotic strain (<i>Lactobacillus salivarius</i> PS7), specifically tailored for its antagonism against otopathogens. Since <i>L. salivarius</i> PS7 was safe and displayed a strong antimicrobial activity against otopathogens, its efficacy in preventing rAOM was assessed in a trial involving 61 children suffering from rAOM. Children consumed daily ~1 × 10<sup>9</sup> CFU of <i>L. salivarius</i> PS7, and the number of AOM episodes were registered and compared with that observed in the previous 6 and 12 months. The microbiota of samples collected from the external auditory canal samples was quantitatively and qualitatively assessed. The number of AOM episodes during the intervention period decreased significantly (84%) when compared to that reported during the 6 months period before the probiotic intervention. In conclusion, <i>L. salivarius</i> PS7 is a promising strain for the prevention of rAOM in infants and children. |
topic |
<i>Lactobacillus salivarius</i> otitis probiotic bacteriocin prevention |
url |
https://www.mdpi.com/2072-6643/11/2/376 |
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