DERMATOSE PUSTULAR SUBCORNEAL DE SNEDDON-WILKINSON
Subcorneal pustular dermatosis is a rare, chronic, relapsing pustular eruption that strikes the corneal layer of the skin and presents with a neutrophilic infiltrate on histopathological examination. It was first described by Sneddon and Wilkinson in 1956 and affects mainly middle-aged and elderly w...
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Sociedade Galega de Medicina Interna
2020-07-01
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doaj-d62629beb4d34678867598d4c38a68c22020-11-25T03:26:08ZengSociedade Galega de Medicina InternaGalicia Clínica0304-48661989-39222020-07-01813939310.22546/57/19191919DERMATOSE PUSTULAR SUBCORNEAL DE SNEDDON-WILKINSONJoão Costelha0Artur Barros1Unidade Local de Saúde do Alto MinhoUnidade Local de Saúde do Alto MinhoSubcorneal pustular dermatosis is a rare, chronic, relapsing pustular eruption that strikes the corneal layer of the skin and presents with a neutrophilic infiltrate on histopathological examination. It was first described by Sneddon and Wilkinson in 1956 and affects mainly middle-aged and elderly women. Its coalescing vesiculopustular eruptions typically involve the flexion sites of the trunk and proximal extremities Its etiology is unknown, but pathophysiological mechanisms are related to an increased tumor necrosis factor-α. It is frequently related to systemic pathologies, particularly hematological (gamopathies, multiple myeloma) and inflammatory diseases (rheumatoid arthritis). The picture is illustrative of a clinical case of an IgA Gamopathy. The diagnosis of dermatosis is established if the classic signal is present (see picture), or a confirmatory histology. Disease without cure, dermatological control´s treatment and prognosis is dependent on systemic associations.https://galiciaclinica.info/publicacion.asp?f=1919dermatosis pustulosa subcornealsneddon y wilkinsongammapatía iga |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
João Costelha Artur Barros |
spellingShingle |
João Costelha Artur Barros DERMATOSE PUSTULAR SUBCORNEAL DE SNEDDON-WILKINSON Galicia Clínica dermatosis pustulosa subcorneal sneddon y wilkinson gammapatía iga |
author_facet |
João Costelha Artur Barros |
author_sort |
João Costelha |
title |
DERMATOSE PUSTULAR SUBCORNEAL DE SNEDDON-WILKINSON |
title_short |
DERMATOSE PUSTULAR SUBCORNEAL DE SNEDDON-WILKINSON |
title_full |
DERMATOSE PUSTULAR SUBCORNEAL DE SNEDDON-WILKINSON |
title_fullStr |
DERMATOSE PUSTULAR SUBCORNEAL DE SNEDDON-WILKINSON |
title_full_unstemmed |
DERMATOSE PUSTULAR SUBCORNEAL DE SNEDDON-WILKINSON |
title_sort |
dermatose pustular subcorneal de sneddon-wilkinson |
publisher |
Sociedade Galega de Medicina Interna |
series |
Galicia Clínica |
issn |
0304-4866 1989-3922 |
publishDate |
2020-07-01 |
description |
Subcorneal pustular dermatosis is a rare, chronic, relapsing pustular eruption that strikes the corneal layer of the skin and presents with a neutrophilic infiltrate on histopathological examination. It was first described by Sneddon and Wilkinson in 1956 and affects mainly middle-aged and elderly women. Its coalescing vesiculopustular eruptions typically involve the flexion sites of the trunk and proximal extremities
Its etiology is unknown, but pathophysiological mechanisms are related to an increased tumor necrosis factor-α. It is frequently related to systemic pathologies, particularly hematological (gamopathies, multiple myeloma) and inflammatory diseases (rheumatoid arthritis). The picture is illustrative of a clinical case of an IgA Gamopathy.
The diagnosis of dermatosis is established if the classic signal is present (see picture), or a confirmatory histology. Disease without cure, dermatological control´s treatment and prognosis is dependent on systemic associations. |
topic |
dermatosis pustulosa subcorneal sneddon y wilkinson gammapatía iga |
url |
https://galiciaclinica.info/publicacion.asp?f=1919 |
work_keys_str_mv |
AT joaocostelha dermatosepustularsubcornealdesneddonwilkinson AT arturbarros dermatosepustularsubcornealdesneddonwilkinson |
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