Effect of Aging on the Quantitative Number of Brunner’s Glands
Background: Age related changes in the number of Brunner’s Glands (BG) in four anatomical parts of human duodenum were studied. The few studies done on this topic were conducted mainly in men. Studies involving a much larger age group, from foetuses to elderly individuals up to 85years of age in...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2014-03-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/4087/2-%207652_F(P)_PF1(PAK)_PFA(AK)_E(V)_PF2(PN)_u.pdf |
Summary: | Background: Age related changes in the number of Brunner’s
Glands (BG) in four anatomical parts of human duodenum were
studied. The few studies done on this topic were conducted
mainly in men. Studies involving a much larger age group, from
foetuses to elderly individuals up to 85years of age including
both sexes were not done earlier and were evaluated.
Aim: To find out whether the number of (BG) differs with increasing
age in the four anatomical parts of duodenum.
Materials and Methods: This study was carried out on the basis
of 74 specimens taken from still-born foetuses. The patients were
divided into four groups as <1-25 years, 26-50 years, 51-75 years
and 76-85 years. Duodenal biopsies without gastrointestinal
disorders were included in the study group. Sections were
prepared and stained with haematoxylin-eosin. Ten microscopic
fields of vision (FOV) were examined under high power on every
representative slide from each duodenal portion and average
was calculated. The (BGs) were analyzed quantitatively. The final
result was expressed as the number of glands per high power
field. The average number of (BG) in field of vision per high power
field for each of the age groups was tabulated for subsequent
statistical study. The documented data was calculated by the
SPSS, version 16.0 software.
Result: The decrease in (BG) is significant (p-value < 0.001) in
the superior (first) and ascending (fourth) part of duodenum in all
the age groups.
Conclusion: It suggests that the number of glands can differ
according to variations in age in duodenum. |
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ISSN: | 2249-782X 0973-709X |