NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.
Bibliographic Details
Main Authors: |
Robert Fledrich,
Dagmar Akkermann,
Vlad Schütza,
Tamer A. Abdelaal,
Doris Hermes,
Erik Schäffner,
M. Clara Soto-Bernardini,
Tilmann Götze,
Axel Klink,
Kathrin Kusch,
Martin Krueger,
Theresa Kungl,
Clara Frydrychowicz,
Wiebke Möbius,
Wolfgang Brück,
Wolf C. Mueller,
Ingo Bechmann,
Michael W. Sereda,
Markus H. Schwab,
Klaus-Armin Nave,
Ruth M. Stassart |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2019-04-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-09385-6
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