NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.

Bibliographic Details
Main Authors: Robert Fledrich, Dagmar Akkermann, Vlad Schütza, Tamer A. Abdelaal, Doris Hermes, Erik Schäffner, M. Clara Soto-Bernardini, Tilmann Götze, Axel Klink, Kathrin Kusch, Martin Krueger, Theresa Kungl, Clara Frydrychowicz, Wiebke Möbius, Wolfgang Brück, Wolf C. Mueller, Ingo Bechmann, Michael W. Sereda, Markus H. Schwab, Klaus-Armin Nave, Ruth M. Stassart
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09385-6
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spelling doaj-d62e39531a3348db81bc0e371f8388cc2021-05-11T12:20:51ZengNature Publishing GroupNature Communications2041-17232019-04-0110111710.1038/s41467-019-09385-6NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathiesRobert Fledrich0Dagmar Akkermann1Vlad Schütza2Tamer A. Abdelaal3Doris Hermes4Erik Schäffner5M. Clara Soto-Bernardini6Tilmann Götze7Axel Klink8Kathrin Kusch9Martin Krueger10Theresa Kungl11Clara Frydrychowicz12Wiebke Möbius13Wolfgang Brück14Wolf C. Mueller15Ingo Bechmann16Michael W. Sereda17Markus H. Schwab18Klaus-Armin Nave19Ruth M. Stassart20Institute of Anatomy, University of LeipzigDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineInstitute of Anatomy, University of LeipzigDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neuropathology, University Hospital LeipzigDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineInstitute of Neuropathology, University Medical Center GöttingenDepartment of Neuropathology, University Hospital LeipzigInstitute of Anatomy, University of LeipzigDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineOnion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.https://doi.org/10.1038/s41467-019-09385-6
collection DOAJ
language English
format Article
sources DOAJ
author Robert Fledrich
Dagmar Akkermann
Vlad Schütza
Tamer A. Abdelaal
Doris Hermes
Erik Schäffner
M. Clara Soto-Bernardini
Tilmann Götze
Axel Klink
Kathrin Kusch
Martin Krueger
Theresa Kungl
Clara Frydrychowicz
Wiebke Möbius
Wolfgang Brück
Wolf C. Mueller
Ingo Bechmann
Michael W. Sereda
Markus H. Schwab
Klaus-Armin Nave
Ruth M. Stassart
spellingShingle Robert Fledrich
Dagmar Akkermann
Vlad Schütza
Tamer A. Abdelaal
Doris Hermes
Erik Schäffner
M. Clara Soto-Bernardini
Tilmann Götze
Axel Klink
Kathrin Kusch
Martin Krueger
Theresa Kungl
Clara Frydrychowicz
Wiebke Möbius
Wolfgang Brück
Wolf C. Mueller
Ingo Bechmann
Michael W. Sereda
Markus H. Schwab
Klaus-Armin Nave
Ruth M. Stassart
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
Nature Communications
author_facet Robert Fledrich
Dagmar Akkermann
Vlad Schütza
Tamer A. Abdelaal
Doris Hermes
Erik Schäffner
M. Clara Soto-Bernardini
Tilmann Götze
Axel Klink
Kathrin Kusch
Martin Krueger
Theresa Kungl
Clara Frydrychowicz
Wiebke Möbius
Wolfgang Brück
Wolf C. Mueller
Ingo Bechmann
Michael W. Sereda
Markus H. Schwab
Klaus-Armin Nave
Ruth M. Stassart
author_sort Robert Fledrich
title NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_short NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_full NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_fullStr NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_full_unstemmed NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_sort nrg1 type i dependent autoparacrine stimulation of schwann cells in onion bulbs of peripheral neuropathies
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-04-01
description Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.
url https://doi.org/10.1038/s41467-019-09385-6
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