NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.
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Nature Publishing Group
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09385-6 |
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doaj-d62e39531a3348db81bc0e371f8388cc2021-05-11T12:20:51ZengNature Publishing GroupNature Communications2041-17232019-04-0110111710.1038/s41467-019-09385-6NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathiesRobert Fledrich0Dagmar Akkermann1Vlad Schütza2Tamer A. Abdelaal3Doris Hermes4Erik Schäffner5M. Clara Soto-Bernardini6Tilmann Götze7Axel Klink8Kathrin Kusch9Martin Krueger10Theresa Kungl11Clara Frydrychowicz12Wiebke Möbius13Wolfgang Brück14Wolf C. Mueller15Ingo Bechmann16Michael W. Sereda17Markus H. Schwab18Klaus-Armin Nave19Ruth M. Stassart20Institute of Anatomy, University of LeipzigDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineInstitute of Anatomy, University of LeipzigDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neuropathology, University Hospital LeipzigDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineInstitute of Neuropathology, University Medical Center GöttingenDepartment of Neuropathology, University Hospital LeipzigInstitute of Anatomy, University of LeipzigDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineDepartment of Neurogenetics, Max-Planck-Institute of Experimental MedicineOnion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.https://doi.org/10.1038/s41467-019-09385-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Robert Fledrich Dagmar Akkermann Vlad Schütza Tamer A. Abdelaal Doris Hermes Erik Schäffner M. Clara Soto-Bernardini Tilmann Götze Axel Klink Kathrin Kusch Martin Krueger Theresa Kungl Clara Frydrychowicz Wiebke Möbius Wolfgang Brück Wolf C. Mueller Ingo Bechmann Michael W. Sereda Markus H. Schwab Klaus-Armin Nave Ruth M. Stassart |
| spellingShingle |
Robert Fledrich Dagmar Akkermann Vlad Schütza Tamer A. Abdelaal Doris Hermes Erik Schäffner M. Clara Soto-Bernardini Tilmann Götze Axel Klink Kathrin Kusch Martin Krueger Theresa Kungl Clara Frydrychowicz Wiebke Möbius Wolfgang Brück Wolf C. Mueller Ingo Bechmann Michael W. Sereda Markus H. Schwab Klaus-Armin Nave Ruth M. Stassart NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies Nature Communications |
| author_facet |
Robert Fledrich Dagmar Akkermann Vlad Schütza Tamer A. Abdelaal Doris Hermes Erik Schäffner M. Clara Soto-Bernardini Tilmann Götze Axel Klink Kathrin Kusch Martin Krueger Theresa Kungl Clara Frydrychowicz Wiebke Möbius Wolfgang Brück Wolf C. Mueller Ingo Bechmann Michael W. Sereda Markus H. Schwab Klaus-Armin Nave Ruth M. Stassart |
| author_sort |
Robert Fledrich |
| title |
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies |
| title_short |
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies |
| title_full |
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies |
| title_fullStr |
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies |
| title_full_unstemmed |
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies |
| title_sort |
nrg1 type i dependent autoparacrine stimulation of schwann cells in onion bulbs of peripheral neuropathies |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-04-01 |
| description |
Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures. |
| url |
https://doi.org/10.1038/s41467-019-09385-6 |
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